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AB228821

Anti-IMUP 抗体 - C-terminal

Anti-IMUP antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal IMUP antibody. C-terminal. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IMUP aa 50 to C-terminus.

別名を表示する

C19orf33, IMUP, Immortalization up-regulated protein, Hepatocyte growth factor activator inhibitor type 2-related small protein, H2RSP, HAI-2-related small protein

1 Images
Immunoprecipitation - Anti-IMUP antibody - C-terminal (AB228821)
  • IP

Supplier Data

Immunoprecipitation - Anti-IMUP antibody - C-terminal (AB228821)

IMUP was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab228821 at 8 μl per reaction. Western blot was performed from the immunoprecipitate using ab228821 at a 1/1000 dilution.

Lane 1 : ab228821 IP in HeLa whole cell lysate.
Lane 2 : Control IgG IP in HeLa whole cell lysate.

Detection : Chemiluminescence with exposure time of 3 minutes.

All lanes:

Immunoprecipitation - Anti-IMUP antibody - C-terminal (ab228821)

Predicted band size: 11 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IP

applications

免疫原

Synthetic Peptide within Human IMUP aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p>Use at a 8 - 15 μl/mg lysate.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab228821 was affinity purified using an epitope specific to IMUP immobilized on solid support.
バッファー組成
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The IMUP protein also known as C19orf33 has a molecular weight of approximately 17 kDa. This small protein is expressed in various tissues across the human body with noticeable levels in immune-related tissues like the spleen and lymph nodes. The specific cellular localization and expression patterns suggest a role in the immune system's functions. Researchers frequently investigate it to understand its potential interactions and effects better.
Biological function summary

IMUP participates in immune system regulation and cellular processes. It does not operate alone but forms part of a protein complex that influences immune responses. This complex is critical in recognizing and responding to foreign antigens aiding the immune system in distinguishing between self and non-self entities. The protein's involvement in cellular signaling pathways indicates its role in managing cell communication and response to environmental changes.

Pathways

The IMUP protein plays roles within immune signaling and inflammatory pathways. For example immune response pathways such as the NF-kB pathway involve IMUP as a modulator. Proteins like TNF-alpha interact closely with IMUP influencing its role in signaling processes that regulate inflammation and cellular survival. These interactions highlight its importance in immune response regulation and complex signaling networks.

IMUP is associated with autoimmune diseases and chronic inflammatory conditions. Researchers have identified its altered expression in autoimmune disorders such as rheumatoid arthritis where it's implicated in the disease's pathogenesis. It interacts with proteins like IL-6 which are known to contribute to the inflammatory environment characteristic of these conditions. Understanding IMUP's involvement in such diseases may offer insights into potential therapeutic targets and treatment strategies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information IMUP
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e30959 PubMed38813227

2024

TFAIP6 facilitates hepatocellular carcinoma cell glycolysis through upregulating c-myc/PKM2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Kecai Duan,Kunpeng Fang,Chengjun Sui

Cell biology and toxicology 39:2069-2087 PubMed35142956

2022

Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.

Applications

Unspecified application

Species

Unspecified reactive species

Qiankun Luo,Yanfeng Pan,Qiang Fu,Xu Zhang,Shuai Zhou,Pengfei Yu,Huiyuan Tian,Pan Liu,Song Chen,Hongwei Zhang,Tao Qin
View all publications
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