Anti-ILP2 抗体 (ab9664)
Key features and details
- Rabbit polyclonal to ILP2
- Suitable for: WB, ICC
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ILP2 antibody -
製品の詳細
Rabbit polyclonal to ILP2 -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICCmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide:
TGYEARLITFGT
, corresponding to amino acids 2-13 of Human ILP2. (Peptide available as ab9665.) -
ポジティブ･コントロール
- WB: HepG2 and MOLT4 cell lysate. ICC: HepG2 cells
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特記事項
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
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製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide -
Concentration information loading... -
精製度
Immunogen affinity purified -
一次抗体 備考
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab9664の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 33 kDa.
|
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| ICC |
Use a concentration of 10 µg/ml.
|
| 特記事項 |
|---|
|
WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 33 kDa. |
|
ICC
Use a concentration of 10 µg/ml. |
ターゲット情報
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機能
Protects against apoptosis mediated by BAX. -
組織特異性
Testis specific in normal tissues. -
配列類似性
Belongs to the IAP family.
Contains 1 BIR repeat.
Contains 1 RING-type zinc finger. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 112401 Human
- SwissProt: Q96P09 Human
- Unigene: 348263 Human
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別名
- Baculoviral IAP repeat containing 8 antibody
- Baculoviral IAP repeat containing protein 8 antibody
- Baculoviral IAP repeat-containing protein 8 antibody
see all
画像
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Western blot - Anti-ILP2 antibody (ab9664)All lanes : Anti-ILP2 antibody (ab9664) at 1 µg/ml
Lane 1 : HepG2 cell lysate
Lane 2 : MOLT4 cell lysate -
Immunocytochemistry - Anti-ILP2 antibody (ab9664)ab9664 at 10µg/ml staining ILP2 in HepG2 cells by Immunocytochemistry.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab9664 は 8 報の論文で使用されています。
- Xiang S et al. Proteomic analysis of inhibitor of apoptosis protein-like protein-2 on breast cancer cell proliferation. Mol Med Rep 25:N/A (2022). PubMed: 35039877
- Wang F et al. Deficient spermiogenesis in mice lacking Rlim. Elife 10:N/A (2021). PubMed: 33620316
- Wen X et al. Overexpression of HOXD8 inhibits the proliferation, migration and invasion of breast cancer cells by downregulating ILP2 expression. Exp Ther Med 22:1006 (2021). PubMed: 34345288
- Mukhtar T et al. Tead transcription factors differentially regulate cortical development. Sci Rep 10:4625 (2020). PubMed: 32170161
- Charish J et al. Neogenin neutralization prevents photoreceptor loss in inherited retinal degeneration. J Clin Invest 130:2054-2068 (2020). PubMed: 32175920
- Jaén RI et al. BML-111 treatment prevents cardiac apoptosis and oxidative stress in a mouse model of autoimmune myocarditis. FASEB J 34:10531-10546 (2020). PubMed: 32543747
- Kong D et al. Protective effects of Asiatic acid against pelvic inflammatory disease in rats. Exp Ther Med 17:4687-4692 (2019). PubMed: 31086602
- Zhu L et al. Inhibitor of apoptosis protein-like protein-2: A novel growth accelerator for breast cancer cells. Oncol Rep 40:2047-2055 (2018). PubMed: 30106449