Anti-IL2 Receptor beta/p75 抗体 (ab61195)
Key features and details
- Rabbit polyclonal to IL2 Receptor beta/p75
- Suitable for: IHC-P, WB
- Reacts with: Human, African green monkey
- Isotype: IgG
製品の概要
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製品名
Anti-IL2 Receptor beta/p75 antibody
IL2 Receptor beta/p75 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to IL2 Receptor beta/p75 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-P, WBmore details -
種交差性
交差種: Human, African green monkey
交差が予測される動物種: Mouse, Rat
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免疫原
Synthetic peptide corresponding to Human IL2 Receptor beta/p75.
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ポジティブ･コントロール
- WB: COS7 cell extracts. IHC-P: Human lung carcinoma tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Without Mg2+ and Ca2+ -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
ab61195 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab61195の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
1/50 - 1/100.
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| WB |
1/500 - 1/1000. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).
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| 特記事項 |
|---|
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IHC-P
1/50 - 1/100. |
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WB
1/500 - 1/1000. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa). |
ターゲット情報
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機能
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. -
配列類似性
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 1 fibronectin type-III domain. -
ドメイン
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3560 Human
- Entrez Gene: 16185 Mouse
- Entrez Gene: 25746 Rat
- Omim: 146710 Human
- SwissProt: P14784 Human
- SwissProt: P16297 Mouse
- SwissProt: P26896 Rat
- Unigene: 474787 Human
see all -
別名
- CD122 antibody
- CD122 antigen antibody
- High affinity IL 2 receptor beta subunit antibody
see all
画像
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Western blot - Anti-IL2 Receptor beta/p75 antibody (ab61195)All lanes : Anti-IL2 Receptor beta/p75 antibody (ab61195) at 1/500 dilution
Lane 1 : COS7 cell extracts
Lane 2 : COS7 cell extracts with immunising peptide
Predicted band size: 61 kDa
Observed band size: 61 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL2 Receptor beta/p75 antibody (ab61195)ab61195 at 1/50 dilution staining IL2 Receptor beta/p75 in human lung carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence (left) or presence (right) of the immunising peptide.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab61195 は 5 報の論文で使用されています。
- Chen K et al. An Apoptotic Gene Signature for the Prognosis of Hepatocellular Carcinoma. Onco Targets Ther 14:1589-1604 (2021). PubMed: 33688206
- Zhang LL et al. Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral T-cell lymphoma expressing the ITK-SYK fusion gene. Int J Oncol 55:1077-1089 (2019). PubMed: 31545408
- Iskandar R et al. Expression of pericardial fluid T-cells and related inflammatory cytokines in patients with chronic heart failure. Exp Ther Med 13:1850-1858 (2017). PubMed: 28565777
- Lu ZH et al. CD25 is a novel marker of hepatic bile canaliculus. Int J Surg Pathol 20:455-61 (2012). ICC/IF ; Human . PubMed: 22576476
- Cohen CJ et al. Placenta-specific Expression of the Interleukin-2 (IL-2) Receptor {beta} Subunit from an Endogenous Retroviral Promoter. J Biol Chem 286:35543-52 (2011). WB ; Human . PubMed: 21865161