Anti-IL-1RA 抗体 (ab175392)
Key features and details
- Rabbit polyclonal to IL-1RA
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-IL-1RA antibody
IL-1RA 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to IL-1RA -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, WBmore details
適用なし: IHC-P -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to Human IL-1RA.
Database link: P18510 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab175392の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF |
1/100.
|
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| WB |
1/1000. Predicted molecular weight: 20 kDa.
|
| 特記事項 |
|---|
|
ICC/IF
1/100. |
|
WB
1/1000. Predicted molecular weight: 20 kDa. |
ターゲット情報
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機能
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. -
組織特異性
The intracellular form of IL1RN is predominantly expressed in epithelial cells. -
関連疾患
Microvascular complications of diabetes 4
Interleukin 1 receptor antagonist deficiency -
細胞内局在
Cytoplasm and Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 3557 Human
- Omim: 147679 Human
- SwissProt: P18510 Human
- Unigene: 81134 Human
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別名
- DIRA antibody
- F630041P17Rik antibody
- ICIL 1RA antibody
see all
画像
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Western blot - Anti-IL-1RA antibody (ab175392)Anti-IL-1RA antibody (ab175392) at 1/1000 dilution + A431 cells at 25 µg
Secondary
HRP Goat Anti-Rabbit IgG (H+L) at 1/10000 dilution
Predicted band size: 20 kDa
Exposure time: 90 secondsBlocking buffer: 3% nonfat dry milk in TBST
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Immunocytochemistry/ Immunofluorescence - Anti-IL-1RA antibody (ab175392)Immunofluorescence analysis of human skin cancer using ab175392 at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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Immunocytochemistry/ Immunofluorescence - Anti-IL-1RA antibody (ab175392)Immunofluorescence analysis of A431 cells using ab175392 at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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Immunocytochemistry/ Immunofluorescence - Anti-IL-1RA antibody (ab175392)Immunofluorescence analysis of HepG2 cells using ab175392 at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab175392 は 3 報の論文で使用されています。
- Li S et al. Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects. Bioact Mater 23:101-117 (2023). PubMed: 36406252
- Gajawada P et al. Myocardial Accumulations of Reg3A, Reg3? and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis. Int J Mol Sci 22:N/A (2021). PubMed: 33923774
- Jurga AM et al. Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors. Pharm Biol 56:275-286 (2018). PubMed: 29656686