Anti-IL-17RA Receptor 抗体 - N-terminal (ab180904)
Key features and details
- Rabbit polyclonal to IL-17RA Receptor - N-terminal
- Suitable for: IHC-P, WB, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-IL-17RA Receptor antibody - N-terminal
IL-17RA Receptor 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to IL-17RA Receptor - N-terminal -
由来種
Rabbit -
特異性
Multiple isoforms of IL-17RA are known to exist. ab180904 is predicted to not cross-react with other IL-17RA Receptor subunits.
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アプリケーション
適用あり: IHC-P, WB, ICC/IFmore details -
種交差性
交差種: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human IL-17RA Receptor (N terminal). 18 amino acid peptide near the N-terminus of Human IL-17RA Receptor .
Database link: Q96F46 -
ポジティブ･コントロール
- A20 cell lysate; Human spleen tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab180904の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
Use a concentration of 2.5 µg/ml.
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| WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 135 kDa (predicted molecular weight: 96 kDa).
WB only validated using mouse samples. |
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| ICC/IF |
Use a concentration of 20 µg/ml.
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| 特記事項 |
|---|
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IHC-P
Use a concentration of 2.5 µg/ml. |
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WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 135 kDa (predicted molecular weight: 96 kDa). WB only validated using mouse samples. |
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ICC/IF
Use a concentration of 20 µg/ml. |
ターゲット情報
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機能
Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. -
組織特異性
Widely expressed. -
関連疾患
Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. -
配列類似性
Contains 1 SEFIR domain. -
翻訳後修飾
Glycosylated. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 23765 Human
- Entrez Gene: 16172 Mouse
- Omim: 605461 Human
- SwissProt: Q96F46 Human
- SwissProt: Q60943 Mouse
- Unigene: 48353 Human
- Unigene: 4481 Mouse
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別名
- CANDF5 antibody
- CD217 antibody
- CD217 antigen antibody
see all
画像
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Western blot - Anti-IL-17RA Receptor antibody - N-terminal (ab180904)Anti-IL-17RA Receptor antibody - N-terminal (ab180904) at 1 µg/ml + A20 cell lysate at 15 µg
Predicted band size: 96 kDa
Additional bands at: 135 kDa. We are unsure as to the identity of these extra bands. -
Immunocytochemistry/ Immunofluorescence - Anti-IL-17RA Receptor antibody - N-terminal (ab180904)Immunofluorescent analysis of Human spleen tissue labeling IL-17RA with ab180904 20 µg/ml.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-17RA Receptor antibody - N-terminal (ab180904)Immunohistochemical analysis of paraffin embedded Human spleen tissue labeling IL-17RA with ab180904 at 2.5 µg/ml.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (14)
ab180904 は 14 報の論文で使用されています。
- Zhang N et al. IL-17F promotes osteoblastic osteogenesis via the MAPK/ERK1/2 signaling pathway. Exp Ther Med 22:1052 (2021). PubMed: 34434266
- Chu S et al. C-EBPβ mediates in cigarette/IL-17A-induced bronchial epithelial-mesenchymal transition in COPD mice. BMC Pulm Med 21:376 (2021). PubMed: 34794427
- Di Filippo M et al. Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis. Cell Rep 37:110094 (2021). PubMed: 34879272
- Ma L et al. Cigarette and IL-17A synergistically induce bronchial epithelial-mesenchymal transition via activating IL-17R/NF-?B signaling. BMC Pulm Med 20:26 (2020). PubMed: 32000730
- Bi CS et al. Calcitriol inhibits osteoclastogenesis in an inflammatory environment by changing the proportion and function of T helper cell subsets (Th2/Th17). Cell Prolif 53:e12827 (2020). PubMed: 32406154
