Anti-IL-15RA 抗体 [RM0103-6C38] (ab86486)
Key features and details
- Rat monoclonal [RM0103-6C38] to IL-15RA
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2a
製品の概要
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製品名
Anti-IL-15RA antibody [RM0103-6C38]
IL-15RA 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [RM0103-6C38] to IL-15RA -
由来種
Rat -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse -
免疫原
Recombinant fragment corresponding to Mouse IL-15RA.
Database link: Q60819 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: PBS -
Concentration information loading... -
特記事項（精製）
The IgG fraction of culture supernatant was purified by protein A/G affinity chromatography and 0.2µm filtered. -
ポリ/モノ
モノクローナル -
クローン名
RM0103-6C38 -
アイソタイプ
IgG2a -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab86486の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
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WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Receptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK. -
組織特異性
Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. -
配列類似性
Contains 1 Sushi (CCP/SCR) domain. -
翻訳後修飾
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Phosphorylated by activated SYK.
N-glycosylated and O-glycosylated. -
細胞内局在
Secreted > extracellular space; Membrane. Nucleus membrane. Mainly found associated with the nuclear membrane and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane. Membrane. Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 16169 Mouse
- SwissProt: Q60819 Mouse
- Unigene: 200196 Mouse
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別名
- AA690181 antibody
- CD215 antibody
- I15RA_HUMAN antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (2)
ab86486 は 2 報の論文で使用されています。
- Takashima A et al. Uterine natural killer cells severely decrease in number at gestation day 6 in mice. Biol Reprod 89:101 (2013). WB ; Mouse . PubMed: 24025738
- Chenoweth MJ et al. IL-15 can signal via IL-15Ra, JNK, and NF-?B to drive RANTES production by myeloid cells. J Immunol 188:4149-57 (2012). Blocking ; Mouse . PubMed: 22447977
