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AB168757

Anti-Ikaros 抗体

Anti-Ikaros antibody

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(1 Publication)

Mouse Polyclonal Ikaros antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IKZF1.

別名を表示する

IK1, IKAROS, LYF1, ZNFN1A1, IKZF1, DNA-binding protein Ikaros, Ikaros family zinc finger protein 1, Lymphoid transcription factor LyF-1

1 Images
Western blot - Anti-Ikaros antibody (AB168757)
  • WB

Unknown

Western blot - Anti-Ikaros antibody (AB168757)

All lanes:

Western blot - Anti-Ikaros antibody (ab168757) at 1 µg/mL

Lane 1:

Ikaros-transfected 293T cell line lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 57 kDa

true

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human IKZF1.

Q13422

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Reactivity data

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Ikaros also known as IKZF1 is a transcription factor. You also find it being referred to as the Ikaros protein or Ikaros code. It has a molecular mass of about 58-60 kDa. Ikaros expresses mostly in hematopoietic cells including precursors from which various blood cell types derive. It plays a significant role in regulating gene expression and cellular differentiation modulating the chromatin structure to control access to DNA.
Biological function summary

Ikaros protein functions in the regulation of lymphoid cell development. It is a part of a chromatin-remodeling complex influencing chromatin accessibility. Through its zinc finger domains it binds to specific DNA sequences controlling genes necessary for lymphocyte differentiation and proliferation. Ikaros influences various cell types within the immune system especially affecting T and B cell development and also regulates cytokine receptor genes necessary for proper immune function.

Pathways

The Ikaros protein is critical to lymphocyte signaling pathways particularly the JAK/STAT and NF-κB pathways. In these pathways Ikaros interacts with other transcription factors like GATA3 and STAT5 integrating signals that are important for immune cell function and development. This integration allows a coordinated response to extracellular signals ensuring effective immune responses or tolerance.

Ikaros is associated with leukemia and lymphomas. Alterations or mutations in ikaros gene can lead to misregulation of its target genes contributing to the development of these diseases by disturbing normal hematopoietic processes. Moreover its interaction with TAL1 protein is significant in certain leukemias where disturbances in the balance of their activities can lead to malignancies. Understanding Ikaros’s role provides insights for therapeutic approaches in these blood disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Transcription regulator of hematopoietic cell differentiation (PubMed : 17934067). Binds gamma-satellite DNA (PubMed : 17135265, PubMed : 19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed : 17135265, PubMed : 17934067).
See full target information IKZF1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Food science & nutrition 12:5100-5110 PubMed39055233

2024

Restoring energy metabolism by NAD supplement prevents alcohol-induced liver injury and boosts liver regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Liu,Cheng Cheng,Han Gao,Xue-Jin Zhu,Xian He,Ming-Xi Zhou,Yuan Gao,Ya-Wen Lu,Xin-Hua Song,Xiao-He Xiao,Jia-Bo Wang,Chun-Jun Xu,Zhi-Tao Ma
View all publications
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代替製品

Primary Antibodies

AB191394

Anti-Ikaros antibody [EPR13790]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ikaros antibody [EPR13790] (AB191394)

  • 0
  • 0
Primary Antibodies

AB229275

Anti-Ikaros antibody - N-terminal

ChIP - Anti-Ikaros antibody - N-terminal (AB229275)

  • 0
  • 0
Primary Antibodies

AB180713

Anti-Ikaros antibody - N-terminal

Immunocytochemistry/ Immunofluorescence - Anti-Ikaros antibody - N-terminal (AB180713)

  • 4
  • 1
Primary Antibodies

AB105228

Anti-Ikaros antibody [SP108]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Ikaros antibody [SP108] (AB105228)

  • 0
  • 0
Primary Antibodies

AB206645

Anti-Ikaros antibody [EPR13790] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ikaros antibody [EPR13790] - BSA and Azide free (AB206645)

  • 0
  • 0
Primary Antibodies

AB236227

Anti-Ikaros antibody [SP108] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Ikaros antibody [SP108] - BSA and Azide free (AB236227)

  • 0
  • 0
Primary Antibodies

AB190691

Anti-Ikaros antibody [EPR13791] - C-terminal

RabMAb|Recombinant

Immunoprecipitation - Anti-Ikaros antibody [EPR13791] - C-terminal (AB190691)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB139408

Anti-IKZF3 antibody [EPR9342(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IKZF3 antibody [EPR9342(B)] (AB139408)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB105227

Anti-ICOS antibody [SP98]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICOS antibody [SP98] (AB105227)

  • 3
  • 2
Primary Antibodies

AB10558

Anti-CD45 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD45 antibody (AB10558)

  • 4
  • 61

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