Anti-IGF1 抗体 [7973] (ab176523)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF1 antibody [7973] (ab176523)](https://www.abcam.co.jp/ps/products/176/ab176523/Images/ab176523-204053-anti-igf1-antibody-7973-immunohistochemistry.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF1 antibody [7973] (ab176523)")
Key features and details
- Mouse monoclonal [7973] to IGF1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-IGF1 antibody [7973]
IGF1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [7973] to IGF1 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Full length protein corresponding to Human IGF1. conjugated to carrier protein - native protein
Database link: P05019 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.03% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
7973 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab176523の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P |
Use a concentration of 1 µg/ml.
|
| 特記事項 |
|---|
|
IHC-P
Use a concentration of 1 µg/ml. |
ターゲット情報
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機能
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. -
関連疾患
Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. -
配列類似性
Belongs to the insulin family. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 3479 Human
- Omim: 147440 Human
- SwissProt: P01343 Human
- SwissProt: P05019 Human
- Unigene: 160562 Human
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製品の状態
There are 2 isoforms produced by alternative splicing. Isoform 1 also known as: IGF-IB; Isoform 2 also known as: IGF-IA. -
別名
- IBP1 antibody
- IGF I antibody
- IGF IA antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF1 antibody [7973] (ab176523)
Immunohistochemical analysis of Formalin Fixed Parafin-embedded normal Human kidney tissue labeling IGF1 with ab176523 at 1ug/ml.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF1 antibody [7973] (ab176523)](https://www.abcam.co.jp/ps/products/176/ab176523/Images/ab176523-204052-anti-igf1-antibody-7973-immunohistochemistry.jpg)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF1 antibody [7973] (ab176523)Immunohistochemical analysis of Formalin Fixed Parafin-embedded normal Human kidney tissue labeling IGF1 with ab176523 at 1ug/ml.
データシートおよび資料
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Datasheet download
参考文献 (8)
ab176523 は 8 報の論文で使用されています。
- Wang F et al. Inhibition of miR-129 Improves Neuronal Pyroptosis and Cognitive Impairment Through IGF-1/GSK3ß Signaling Pathway: An In Vitro and In Vivo Study. J Mol Neurosci N/A:N/A (2021). PubMed: 33484421
- Ye Z et al. Prevention of lumbar disc degeneration through co-manipulation of insulin-like growth factor 1 and vascular endothelial growth factor. Ann Transl Med 9:1572 (2021). PubMed: 34790778
- Sugawara S et al. Increase in IGF-1 Expression in the Injured Infraorbital Nerve and Possible Implications for Orofacial Neuropathic Pain. Int J Mol Sci 20:N/A (2019). PubMed: 31861182
- Ogundele OM et al. A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIa Phosphorylation. Front Neuroanat 12:35 (2018). PubMed: 29867375
- Popovics P et al. Growth hormone-releasing hormone antagonists reduce prostatic enlargement and inflammation in carrageenan-induced chronic prostatitis. Prostate 78:970-980 (2018). PubMed: 29786867
- Ogundele OM et al. Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIa expression in neural changes associated with a prolonged exposure therapy. Neuroscience 353:147-165 (2017). WB ; Rat . PubMed: 28438613
- Li J et al. Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism. Stem Cell Res Ther 8:55 (2017). WB, IHC . PubMed: 28279229
- Tang Y et al. Use of ultrasound-targeted microbubble destruction to transfect IGF-1 cDNA to enhance the regeneration of rat wounded Achilles tendon in vivo. Gene Ther 22:610-8 (2015). PubMed: 25840275
