Anti-IFNAR2 抗体 (ab56070)
Key features and details
- Rabbit polyclonal to IFNAR2
- Suitable for: ELISA, ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-IFNAR2 antibody
IFNAR2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to IFNAR2 -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, ICC/IF, WBmore details -
種交差性
交差種: Human -
免疫原
A synthetic peptide corresponding to C terminal residues of human IFNAR2 (Interferon-alpha/beta receptor beta chain precursor)
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
Purified by antigen specific affinity chromatography. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab56070の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| ICC/IF | (1) |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration. Predicted molecular weight: 57 kDa.
Two hour incubation. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
| 特記事項 |
|---|
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ELISA
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 57 kDa. Two hour incubation. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein. |
ターゲット情報
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機能
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. -
組織特異性
Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. -
配列類似性
Belongs to the type II cytokine receptor family. -
翻訳後修飾
Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated. -
細胞内局在
Secreted and Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3455 Human
- Omim: 602376 Human
- SwissProt: P48551 Human
- Unigene: 708195 Human
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別名
- Human interferon alpha/beta receptor antibody
- IFN alpha REC antibody
- IFN R antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (8)
ab56070 は 8 報の論文で使用されています。
- Deng Y et al. Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses. EBioMedicine 70:103477 (2021). PubMed: 34284174
- Lundtoft C et al. Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling. PLoS Genet 16:e1009199 (2020). PubMed: 33104735
- Lloyd AF et al. Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nat Neurosci 22:1046-1052 (2019). PubMed: 31182869
- Cheng M et al. Interferon down-regulation of miR-1225-3p as an antiviral mechanism through modulating Grb2-associated binding protein 3 expression. J Biol Chem 293:5975-5986 (2018). PubMed: 29496996
- Yang Q et al. Interferon-a inhibits cell migration and invasion and induces the expression of antiviral proteins in Huh-7 cells transfected with hepatitis B virus X gene-expressing lentivirus. Exp Ther Med 14:5924-5930 (2017). PubMed: 29285141
- Happold C et al. Interferon-ß induces loss of spherogenicity and overcomes therapy resistance of glioblastoma stem cells. Mol Cancer Ther 13:948-61 (2014). PubMed: 24526161
- Hong XX & Carmichael GG Innate immunity in pluripotent human cells: attenuated response to interferon-ß. J Biol Chem 288:16196-205 (2013). Human . PubMed: 23599426
- Ghosh D et al. A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress. Proc Natl Acad Sci U S A 105:11673-8 (2008). IP ; Human . PubMed: 18687895