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AB268059

Anti-ICOS Ligand/ICOSL 抗体 [ICOSL/3260]

Anti-ICOS Ligand/ICOSL antibody [ICOSL/3260]

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(1 Publication)

Mouse Monoclonal ICOS Ligand/ICOSL antibody. Suitable for Protein Array, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ICOSLG aa 1-150.

別名を表示する

CD275, B7H2, B7RP1, ICOSL, KIAA0653, ICOSLG, ICOS ligand, B7 homolog 2, B7-like protein Gl50, B7-related protein 1, B7-H2, B7RP-1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICOS Ligand/ICOSL antibody [ICOSL/3260] (AB268059)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ICOS Ligand/ICOSL antibody [ICOSL/3260] (AB268059)

Formalin-fixed, paraffin-embedded human colon carcinoma tissue stained with ab268059 at 2 ug/ml in immunohistochemical analysis.

Protein Array - Anti-ICOS Ligand/ICOSL antibody [ICOSL/3260] (AB268059)
  • Protein Array

Unknown

Protein Array - Anti-ICOS Ligand/ICOSL antibody [ICOSL/3260] (AB268059)

Protein Array containing more than 19,000 full-length human proteins using ab268059. Z- and S- Score : The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

ICOSL/3260

アイソタイプ

IgG2b

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Human

アプリケーション

Protein Array, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human ICOSLG aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

O75144

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代替製品

Primary Antibodies

AB239524

Anti-ICOS Ligand/ICOSL antibody [EPR20786] - BSA and Azide free

RabMAb|Recombinant

Immunoprecipitation - Anti-ICOS Ligand/ICOSL antibody [EPR20786] - BSA and Azide free (AB239524)

  • 0
  • 0
Primary Antibodies

AB248080

Anti-ICOS Ligand/ICOSL antibody [EPR6071] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-ICOS Ligand/ICOSL antibody [EPR6071] - BSA and Azide free (AB248080)

  • 0
  • 0
Primary Antibodies

AB251502

Anti-ICOS Ligand/ICOSL antibody [EPR20240] - BSA and Azide free

RabMAb|Recombinant

Immunoprecipitation - Anti-ICOS Ligand/ICOSL antibody [EPR20240] - BSA and Azide free (AB251502)

  • 0
  • 0
Primary Antibodies

AB230946

Anti-ICOS Ligand/ICOSL antibody [EPR20786]

RabMAb|Recombinant

Immunoprecipitation - Anti-ICOS Ligand/ICOSL antibody [EPR20786] (AB230946)

  • 0
  • 0
Primary Antibodies

AB124972

Anti-ICOS Ligand/ICOSL antibody [EPR6071]

RabMAb|Recombinant

Western blot - Anti-ICOS Ligand/ICOSL antibody [EPR6071] (AB124972)

  • 0
  • 0

組合せ製品

Assay Kits

AB272475

Human ICOS Ligand ELISA Kit (B7-H2)

Recombinant|SimpleStep

Sandwich ELISA - Human ICOS Ligand ELISA Kit (B7-H2) (AB272475)

  • 0
  • 0
Primary Antibodies

AB208670

Anti-Myeloperoxidase antibody [EPR20257]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Myeloperoxidase antibody [EPR20257] (AB208670)

  • 5
  • 7
Primary Antibodies

AB270797

Anti-CD1c antibody [EPR23189-196] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD1c antibody [EPR23189-196] - BSA and Azide free (AB270797)

  • 4
  • 4
Primary Antibodies

AB307627

Alexa Fluor® 555 Anti-CD66b antibody [EPR25354-2]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-CD66b antibody [EPR25354-2] (AB307627)

  • 0
  • 0
Primary Antibodies

AB309369

Alexa Fluor® 488 Anti-HLA-DR antibody [TAL 1B5]

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-HLA-DR antibody [TAL 1B5] (AB309369)

  • 5
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ProteinArray" : {"fullname" : "Protein Array", "shortname":"Protein Array"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ProteinArray-species-checked": "testedAndGuaranteed", "ProteinArray-species-dilution-info": "", "ProteinArray-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
精製に関する特記事項
Purified from Bioreactor concentrate
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The ICOS Ligand also known as ICOSL B7-H2 and HK53 is a critical component in immune system function. This protein with a molecular mass of approximately 65 kDa is expressed on professional antigen-presenting cells such as dendritic cells macrophages and B cells. It plays a significant mechanical role in the immune response by engaging with its counter receptor the ICOS protein present on the surface of activated T cells. This interaction supports the regulation of T cell activity influencing proliferation and cytokine production.
Biological function summary

ICOSL contributes to the modulation of immune responses. By forming a complex with the active ICOS protein ICOSL is involved in the co-stimulation of T cells. This process is important for the development of T-cell-dependent immune responses and helps in promoting the survival and differentiation of T cells. Together the ICOS ligand and ICOS protein create a dynamic interaction that balances immune activation and tolerance which is essential for maintaining immune homeostasis.

Pathways

The ICOS-ICOSL interaction plays an important role in the T-cell receptor (TCR) signaling pathway. This pathway is fundamental for the activation of T cells and subsequent immune response. ICOSL also connects to the PI3K/Akt pathway where it impacts cell survival and proliferation. ICOS and the PI3K/Akt pathway work together to influence various aspects of immune regulation and adaptive immunity.

ICOSL has a notable impact on autoimmune diseases and cancer. Its function in immune modulation when dysregulated can contribute to autoimmune conditions such as systemic lupus erythematosus. In this context the abnormal activation of the ICOS protein may exaggerate immune responses leading to pathology. In cancer high expression of ICOSL can support tumor progression by affecting the immune surveillance capability. These associations reveal ICOSL’s role in balancing immune activation and inhibition which is important in the context of disease.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed : 11007762, PubMed : 11023515, PubMed : 30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed : 30498080).
See full target information ICOSLG
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 21:700 PubMed37805545

2023

Novel role for epalrestat: protecting against NLRP3 inflammasome-driven NASH by targeting aldose reductase.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Shi,Guang Xu,Yuan Gao,Jun Zhao,Tingting Liu,Jia Zhao,Huijie Yang,Ziying Wei,Hui Li,An-Long Xu,Zhaofang Bai,Xiaohe Xiao
View all publications
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Abcam product promise

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