Anti-ICER 抗体 (ab64832)
Key features and details
- Rabbit polyclonal to ICER
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ICER antibody
ICER 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ICER -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human ICER (internal sequence).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Without Mg2+ and Ca2+ -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab64832の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (1) |
1/500 - 1/1000. Detects a band of approximately 34 kDa (predicted molecular weight: 37 kDa).
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| 特記事項 |
|---|
|
WB
1/500 - 1/1000. Detects a band of approximately 34 kDa (predicted molecular weight: 37 kDa). |
ターゲット情報
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機能
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. -
組織特異性
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. -
配列類似性
Belongs to the bZIP family.
Contains 1 bZIP (basic-leucine zipper) domain.
Contains 1 KID (kinase-inducible) domain. -
翻訳後修飾
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
Stimulated by phosphorylation. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 1390 Human
- Omim: 123812 Human
- SwissProt: Q03060 Human
- Unigene: 200250 Human
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別名
- cAMP response element modulator antibody
- cAMP responsive element modulator antibody
- cAMP-responsive element modulator antibody
see all
画像
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Western blot - Anti-ICER antibody (ab64832)All lanes : Anti-ICER antibody (ab64832) at 1/500 dilution
Lane 1 : K562 cell extract
Lane 2 : K562 cell extract with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size: 37 kDa
Observed band size: 34 kDa why is the actual band size different from the predicted?
Additional bands at: 25 kDa. We are unsure as to the identity of these extra bands.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab64832 は 4 報の論文で使用されています。
- Yang Q et al. TGFB1 represses the expression of SF1 and LRH1 to inhibit E2 production in rat LCs. Reproduction 153:621-629 (2017). PubMed: 28250236
- Johansson EM et al. Sex-related differences of cAMP-specific PDE4B3 mRNA in oligodendrocytes following systemic inflammation. Glia : (2012). WB . PubMed: 22848007
- Yabuta Y et al. TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. J Cell Biol 192:781-95 (2011). IHC-Fr ; Mouse . PubMed: 21383078
- Granata R et al. Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart. Cardiovasc Res 83:303-12 (2009). WB ; Rat . PubMed: 19293247