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リコンビナントRabMAb

Anti-HYAL1 抗体 [EPR5542] (ab180143)

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Western blot - Anti-HYAL1 antibody [EPR5542] (ab180143)
  • Anti-HYAL1 antibody [EPR5542] (ab180143)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR5542] to HYAL1
  • Suitable for: WB
  • Reacts with: Human

Conjugates logo Related conjugates and formulations

Carrier Free

製品の概要

  • 製品名

    Anti-HYAL1 antibody [EPR5542]
    HYAL1 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR5542] to HYAL1

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: WBmore details

  • 種交差性

    交差種: Human

  • 免疫原

    Synthetic peptide within Human HYAL1 aa 350 to the C-terminus (C terminal). The exact sequence is proprietary.
    Database link: Q12794

  • ポジティブ･コントロール

    • HepG2, LnCap and HT-1376 cell lysates.

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab180143の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB
1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 48 kDa).
特記事項
WB
1/1000. Detects a band of approximately 60 kDa (predicted molecular weight: 48 kDa).

ターゲット情報

  • 機能

    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

  • 組織特異性

    Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.

  • 関連疾患

    Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.

  • 配列類似性

    Belongs to the glycosyl hydrolase 56 family.
    Contains 1 EGF-like domain.

  • 細胞内局在

    Secreted. Lysosome.
  • Information by UniProt

  • 参照データベース

    • 別名

      • HYAL 1 antibody
      • Hyal-1 antibody
      • HYAL1 antibody
      • HYAL1_HUMAN antibody
      • Hyaluronidase 1 antibody
      • Hyaluronidase-1 antibody
      • Hyaluronoglucosaminidase 1 antibody
      • Hyaluronoglucosaminidase-1 antibody
      • Hyaluronoglucosaminidase1 antibody
      • LUCA 1 antibody
      • LUCA-1 antibody
      • LUCA1 antibody
      • Lung carcinoma protein 1 antibody
      • MGC45987 antibody
      • NAT6 antibody
      • Plasma hyaluronidase antibody
      • Tumor suppressor LUCA 1 antibody
      see all

    画像

    • Western blot - Anti-HYAL1 antibody [EPR5542] (ab180143)
      Western blot - Anti-HYAL1 antibody [EPR5542] (ab180143)
      All lanes : Anti-HYAL1 antibody [EPR5542] (ab180143) at 1/1000 dilution

      Lane 1 : HepG2 cell lysate
      Lane 2 : LnCap cell lysate
      Lane 3 : HT-1376 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

      Predicted band size: 48 kDa
      Observed band size: 60 kDa why is the actual band size different from the predicted?



      Blocking buffer and concentration: 5%NFDM/TBST

    • Anti-HYAL1 antibody [EPR5542] (ab180143)
      Anti-HYAL1 antibody [EPR5542] (ab180143)

    参考文献 (0)

    ab180143 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab180143 は論文での使用が確認できていません。

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