JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB21112

Anti-HSV2 抗体

Anti-HSV2 antibody

Be the first to review this product! Submit a review

|

(4 Publications)

Sheep Polyclonal HSV2 antibody. Suitable for ELISA, WB, Conjugation, ICC/IF, IM and reacts with Human herpesvirus 2 samples. Cited in 4 publications. Immunogen corresponding to Virus preparation containing HSV2 protein.

別名を表示する

Herpes Simplex Virus Type 2

Key facts

宿主種

Sheep

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human herpesvirus 2

アプリケーション

WB, Conjugation, IM, ICC/IF, ELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "Conjugation" : {"fullname" : "Conjugation", "shortname":"Conjugation"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IM" : {"fullname" : "Immunomicroscopy", "shortname":"IM"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human herpesvirus 2": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "Conjugation-species-checked": "guaranteed", "Conjugation-species-dilution-info": "", "Conjugation-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IM-species-checked": "guaranteed", "IM-species-dilution-info": "", "IM-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Ion exchange chromatography
精製に関する特記事項
>95% pure. Sodium sulphate precipitation and ion exchange chromatography.
バッファー組成
Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Herpes Simplex Virus type 2 (HSV2) also known as Human Herpesvirus 2 is a member of the herpesviridae family. It mainly affects the genital region and is a common cause of genital herpes. The virus has a double-stranded DNA genome with a mass of approximately 152 kbp. HSV2 primarily expresses in epithelial cells of the skin and mucous membranes. It can establish latency in neuronal cells especially the sacral ganglia contributing to its ability to persist in the host for life.
Biological function summary

HSV2 exhibits a complex life cycle involving both lytic and latent phases. During infection the virus interacts with cellular compartments including the nucleus where it hijacks host cell machinery to replicate its genome. In the latent phase HSV2 becomes dormant in sensory neurons avoiding host immune detection. It is not part of a larger complex but relies on numerous viral proteins for successful replication and invasion such as glycoproteins critical for host entry.

Pathways

HSV2 interacts with multiple immune evasion and inflammatory pathways. It manipulates the NF-kB signaling pathway an important player in inflammation and immune responses. The virus evades immune detection by inhibiting the activation of NF-kB allowing persistent infection. HSV2 also affects the MAPK signaling pathway through viral proteins such as ICP34.5 which modulate host defense mechanisms and facilitate viral replication.

HSV2 is significantly associated with genital herpes and is linked to an increased risk of HIV acquisition. Genital herpes can cause recurrent painful lesions and can be transmitted to neonates during childbirth leading to neonatal herpes. The virus's interaction with host immune pathways might also modify the host's susceptibility to other sexually transmitted infections including HIV. HSV2 through its impact on the host's immune response shares interactions with proteins like HIV-1 gp120 in co-infected individuals which complicates the management of these infections.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

See full target information HSV2
style
left-column

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 13:983502 PubMed36211339

2022

Herpes simplex virus type 2 inhibits TNF-α-induced NF-κB activation through viral protein ICP22-mediated interaction with p65.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Hu,Ming Fu,Chuntian Li,Binman Zhang,Yuncheng Li,Qinxue Hu,Mudan Zhang

Human gene therapy 33:649-663 PubMed35272497

2022

Bispecific Antibody Expressed by an Oncolytic Herpes Simplex Virus Type 2 Can Transform Heterologous T Cells Into Uniform Tumor Killer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Jin,Runyang Wang,Junhan Yang,Han Hu,Di Wang,Linkang Cai,Zhizheng Fang,Shuang Dong,Sheng Hu,Yang Wang,Binlei Liu

Frontiers in microbiology 10:2790 PubMed31849920

2019

Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2.

Applications

Unspecified application

Species

Unspecified reactive species

Martin Michaelis,Malte C Kleinschmidt,Denisa Bojkova,Holger F Rabenau,Mark N Wass,Jindrich Cinatl

Frontiers in immunology 9:2932 PubMed30619292

2018

Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4 T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4.

Applications

Unspecified application

Species

Unspecified reactive species

Mudan Zhang,Xu Deng,Xinmeng Guan,Lanlan Geng,Ming Fu,Binman Zhang,Rui Chen,Huimin Hu,Kai Hu,Di Zhang,Mei Li,Yalan Liu,Sitang Gong,Qinxue Hu
View all publications
style
left-column
style
left-column
style
right-column

組合せ製品

Primary Antibodies

AB110227

Anti-HSV1 gH antibody [BBH1]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 gH antibody [BBH1] (AB110227)

  • 0
  • 0
Primary Antibodies

AB52552

Anti-Varicella Zoster Virus gI antibody [8C4]

Immunocytochemistry/ Immunofluorescence - Anti-Varicella Zoster Virus gI antibody [8C4] (AB52552)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB6513

Anti-HSV1 ICP0 antibody [5H7]

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 ICP0 antibody [5H7] (AB6513)

  • 5
  • 1

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com