AB6507

Anti-HSV1 + HSV2 gD 抗体 [2C10]

Name: Anti-HSV1 + HSV2 gD 抗体 [2C10] (ab6507) | Abcam
Brand: Abcam Limited
SKU: AB6507
Price: 61000 JPY
Availability: InStock
Rating: 5 (1 reviews)

Anti-HSV1 + HSV2 gD antibody [2C10]

(1 Review)

(28 Publications)

Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507) is a mouse monoclonal antibody detecting HSV1 + HSV2 gD in Western Blot, ICC/IF. Suitable for Herpes simplex virus, Human herpesvirus 2.

- Over 20 publications
- Trusted since 2001

別名を表示する

US6, gD, Envelope glycoprotein D

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

Immunocytochemistry/Immunofluorescence analysis of vero cells infected with HSV1 (left) or HSV2 (right) labelled with ab6507.

Unknown

Western blot - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

The WB was completed using the HSV-1 Antigen and the HSV-2 Infected Cell Extract at 10 μg/cm

All lanes:

Western blot - Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507)

Observed band size: 55 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

2C10

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

キャリアフリー

Yes

交差種

Human herpesvirus 2, Herpes simplex virus

アプリケーション

ICC/IF, WB

applications

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Herpes simplex virus": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/3200 - 1/25600", "ICCIF-species-notes": "1/3,200 (HSV-2) - 1/25,600 (HSV-1).", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000", "WB-species-notes": "" }, "Human herpesvirus 2": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/3200 - 1/25600", "ICCIF-species-notes": "1/3,200 (HSV-2) - 1/25,600 (HSV-1).", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000", "WB-species-notes": "" } } }

style

left-column

製品の詳細

What is this antibody validated in?
Anti-HSV1 + HSV2 gD antibody [2C10] (ab6507) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry/immunofluorescence (ICC/IF) in Herpes simplex virus, Human herpesvirus 2 samples.

Trusted by the scientific community
Anti-HSV1 + HSV2 gD [2C10] (ab6507) was first used in a scientific publication in 2001 and has been cited over 20 times in peer-reviewed journals.

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

HSV1 and HSV2 glycoprotein D (gD) are envelope proteins found on the surfaces of herpes simplex viruses 1 and 2. The gD protein plays a critical role in the virus life cycle by mediating entry into host cells. It binds with cellular receptors initiating membrane fusion necessary for viral entry. Glycoprotein D is approximately 38 kDa in mass and expresses mainly on the surfaces of infected cells and virion particles. These proteins serve as important targets for immune recognition and are often key in vaccine design strategies.

Biological function summary

The gD protein engages with specific cellular receptors like nectin-1 HVEM and others for initiating viral infection. This interaction facilitates the fusion of the viral envelope with the host cell membrane. Glycoprotein D is a part of the larger complex of herpesvirus envelope glycoproteins which work together to enable efficient cell entry and subsequent viral propagation. This coordination within the protein complex ensures the proper attachment and penetration of host cells.

Pathways

The gD proteins interact critically within pathways necessary for viral fusion and entry. Their relationship with proteins like glycoproteins B and H/L within the herpes virus entry mechanism is especially important. Glycoprotein B for example acts after gD-receptor binding to promote the fusion of viral and cell membranes. The fusion and entry pathway dictate the overall success of viral invasion and replication within the host organism.

Herpes simplex viruses 1 and 2 associated with the gD protein are most known for causing oral and genital herpes infections. These two forms of infection only require the presence of gD and its interaction with cellular receptors. Additionally gD is linked to herpes-related encephalitis an inflammation of brain tissue caused by the virus. The understanding of gD and its interaction with human cellular proteins offers potential therapeutic and vaccine development pathways potentially helping to manage and control herpes-related health conditions.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells (PubMed : 22146396). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).

See full target information gD

追加のターゲット

style

left-column

文献 (28)

Recent publications for all applications. Explore the full list and refine your search

Virology journal 22:249 PubMed40684179

2025

Small molecule UCM05 inhibits HSV-2 infection via targeting viral glycoproteins and fatty acid synthase with potentiating antiviral immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Songshan Li,Minghan Li,Yantong Cai,Jun Xian,Rongrong Zhu,Chan Yang,Xin Zhang,Shuya Ren,Aijiao Yu,Shuwen Liu,Bin Yang

Molecular therapy. Nucleic acids 36:102444 PubMed39897577

2025

Extracellular viral microRNAs as biomarkers of virus infection in human cells.

Applications

Unspecified application

Species

Unspecified reactive species

Cheryl Chan,Joanne Xin Yi Loh,Wei-Xiang Sin,Denise Bei Lin Teo,Nicholas Kwan Zen Tan,Chandramouli Nagarajan,Yunxin Chen,Francesca Lorraine Wei Inng Lim,Michael E Birnbaum,Rohan B H Williams,Stacy L Springs

EMBO reports 26:720-747 PubMed39747662

2025

HDAC6 deacetylates TRIM56 to negatively regulate cGAS-STING-mediated type I interferon responses.

Applications

Unspecified application

Species

Unspecified reactive species

Qiongzhen Zeng,Zixin Chen,Shan Li,Ziwei Huang,Zhe Ren,Cuifang Ye,Xiao Wang,Jun Zhou,Kaisheng Liu,Kai Zheng,Yifei Wang

Viruses 16: PubMed39205282

2024

CFTR Inhibitors Display Antiviral Activity against Herpes Simplex Virus.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Jiang,Zhong Dai,Chan Yang,Liqiong Ding,Songshan Li,Xinfeng Xu,Chen Cheng,Jinshen Wang,Shuwen Liu

Brain pathology (Zurich, Switzerland) 33:e13116 PubMed36064300

2022

Aβ plaques do not protect against HSV-1 infection in a mouse model of familial Alzheimer's disease, and HSV-1 does not induce Aβ pathology in a model of late onset Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Olga V Bocharova,Aidan Fisher,Narayan P Pandit,Kara Molesworth,Olga Mychko,Alison J Scott,Natallia Makarava,Rodney Ritzel,Ilia V Baskakov

ACS infectious diseases 8:2084-2095 PubMed36062478

2022

Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[]urils.

Applications

Unspecified application

Species

Unspecified reactive species

Luke M Jones,Elana H Super,Lauren J Batt,Matteo Gasbarri,Francesco Coppola,Lorraine M Bhebhe,Benjamin T Cheesman,Andrew M Howe,Petr Král,Roger Coulston,Samuel T Jones

Current protocols 2:e483 PubMed35822836

2022

Receptor Interactome Discovery with RDIMIS, a Membrane Protein Interaction Screen Using Recombinant Extracellular Vesicles.

Applications

Unspecified application

Species

Unspecified reactive species

Ariana D Sanchez,Sean M Peterson,Mike Reichelt,Christian M Amador,Nadia Martinez-Martin,Shengya Cao

Viruses 14: PubMed35746758

2022

Oleanolic Acid Derivative AXX-18 Exerts Antiviral Activity by Inhibiting the Expression of HSV-1 Viral Genes UL8 and UL52.

Applications

Unspecified application

Species

Unspecified reactive species

Zhaoyang Wang,Jiaoyan Jia,Yuzhou Jiang,Feng Li,Yiliang Wang,Xiaowei Song,Shurong Qin,Yifei Wang,Kai Zheng,Binyuan Hu,Yongxian Cheng,Zhe Ren

Journal of virology 96:e0217821 PubMed35045266

2022

An ESCRT/VPS4 Envelopment Trap To Examine the Mechanism of Alphaherpesvirus Assembly and Transport in Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jenna Barnes,Bryen A Jordan,Duncan W Wilson

Molecular biology 55:413-423 PubMed34931092

2021

Preventive Vaccination with Mesenchymal Stem Cells Protects Mice from Lethal Infection Caused by Herpes Simplex Virus 1.

Applications

Unspecified application

Species

Unspecified reactive species

R R Klimova,N A Demidova,O V Masalova,A A Kushch

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-HSV1 + HSV2 gD 抗体 [2C10]

Anti-HSV1 + HSV2 gD antibody [2C10]

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

Western blot - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

追加のターゲット

文献 (28)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise