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AB20536

Anti-HSV1 抗体

Anti-HSV1 antibody

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(2 Publications)

Goat Polyclonal HSV1 antibody. Suitable for ELISA, WB, IHC-P, IHC-Fr and reacts with Herpes simplex virus samples. Cited in 2 publications. Immunogen corresponding to Virus preparation containing HSV1 protein.

別名を表示する

Herpes simplex virus, Herpes simplex virus 1, Herpes simplex virus type 1, Human Herpesvirus 1, Human herpesvirus type 1

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Herpes simplex virus

アプリケーション

ELISA, IHC-P, IHC-Fr, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Herpes simplex virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/5000", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製度
IgG fraction
バッファー組成
pH: 7.2 Preservative: 0.05% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Add glycerol to a final volume of 50% for extra stability and aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Herpes Simplex Virus 1 (HSV1) also referred to as HSV-1 is an enveloped virus with a large double-stranded DNA genome of about 152 kb. HSV1 possesses a complex architecture featuring numerous glycoproteins including gHSV1 that play significant roles in its entry and immune evasion. This virus predominantly targets epithelial cells in the oral genital regions and sensory neurons. HSV1 expresses various proteins vital for its replication and viral particle assembly within host cells.
Biological function summary

HSV1 interacts with the host's cellular mechanisms to establish latency and persistent infection. During infection several HSV1 proteins contribute to its ability to subvert and evade the host immune response sometimes forming part of existing viral protein complexes. Virion-host cell membrane fusion facilitated by glycoprotein gHSV1 is an important step allowing the viral genome to enter the host cell driving subsequent viral replication.

Pathways

The life cycle of HSV1 includes entry replication and egress tightly integrated into cellular pathways like the apoptosis and the interferon response pathways. HSV1 modulates the apoptotic pathway through proteins such as ICP22 which allows survival and efficient viral replication. Also it influences the interferon response pathway by inhibiting the host's antiviral mechanisms ensuring viral persistence in the host.

HSV1 is most commonly known to cause oral herpes and can lead to encephalitis in severe cases. The virus reactivates from latency within neurons potentially leading to periodic disease recurrence. During infection HSV1 interacts with host proteins such as TNF-alpha which can contribute to inflammatory responses and ICP0 which facilitates viral replication and disrupts host cell function. Understanding HSV1's mechanisms and pathways is critical for developing effective anti-HSV-1 antibodies and therapeutic strategies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information HSV1
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Clinical cancer research : an official journal of the American Association for Cancer Research 28:5419-5430 PubMed36239623

2022

Safety and Efficacy of Intraventricular Immunovirotherapy with Oncolytic HSV-1 for CNS Cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Kyung-Don Kang,Joshua D Bernstock,Stacie K Totsch,Sam E Gary,Abbey Rocco,Li Nan,Rong Li,Tina Etminan,Xiaosi Han,Elizabeth A Beierle,Tanja Eisemann,Robert J Wechsler-Reya,Sejong Bae,Richard Whitley,G Yancey Gillespie,James M Markert,Gregory K Friedman

Cell 132:935-44 PubMed18358807

2008

PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.

Applications

Unspecified application

Species

Unspecified reactive species

Takeshi Satoh,Jun Arii,Tadahiro Suenaga,Jing Wang,Amane Kogure,Junji Uehori,Noriko Arase,Ikuo Shiratori,Shinya Tanaka,Yasushi Kawaguchi,Patricia G Spear,Lewis L Lanier,Hisashi Arase
View all publications
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代替製品

Primary Antibodies

AB234332

Anti-HSV1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody (AB234332)

  • 5
  • 1
Primary Antibodies

AB20306

HRP Anti-HSV1 antibody

  • 0
  • 0
Primary Antibodies

AB20437

FITC Anti-HSV1 antibody

  • 0
  • 0
Primary Antibodies

AB9533

Anti-HSV1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody (AB9533)

  • 5
  • 2
Primary Antibodies

AB236307

Anti-HSV1 antibody - BSA and Azide free

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSV1 antibody - BSA and Azide free (AB236307)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB6507

Anti-HSV1 + HSV2 gD antibody [2C10]

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gD antibody [2C10] (AB6507)

  • 5
  • 1
Primary Antibodies

AB272686

Anti-VZV gE protein antibody [#9]

Western blot - Anti-VZV gE protein antibody [#9] (AB272686)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB6506

Anti-HSV1 + HSV2 gB antibody [10B7]

Immunocytochemistry/ Immunofluorescence - Anti-HSV1 + HSV2 gB antibody [10B7] (AB6506)

  • 0
  • 0

Abcam product promise

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