Anti-Hsp105/HSP110 抗体 (ab24503)
Key features and details
- Rabbit polyclonal to Hsp105/HSP110
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Hsp105/HSP110 antibody
Hsp105/HSP110 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Hsp105/HSP110 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 3390 Hsp105 Antibody. 3390-100 is the same size as the 100 µg size of ab24503.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab24503の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 97 kDa).
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| 特記事項 |
|---|
|
WB
Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 97 kDa). |
ターゲット情報
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機能
Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. -
組織特異性
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. -
配列類似性
Belongs to the heat shock protein 70 family. -
翻訳後修飾
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 10808 Human
- Omim: 610703 Human
- SwissProt: Q92598 Human
- Unigene: 36927 Human
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別名
- Antigen NY CO 25 antibody
- Antigen NY-CO-25 antibody
- DKFZp686M05240 antibody
see all
画像
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Western blot - Anti-Hsp105/HSP110 antibody (ab24503)Anti-Hsp105/HSP110 antibody (ab24503) (1 - 4 ug/ml) + HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7898)
Predicted band size: 97 kDa
Observed band size: 105 kDa why is the actual band size different from the predicted?
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab24503 は 1 報の論文で使用されています。
- Shorter J The Mammalian disaggregase machinery: hsp110 synergizes with hsp70 and hsp40 to catalyze protein disaggregation and reactivation in a cell-free system. PLoS One 6:e26319 (2011). IP ; Human, Rat . PubMed: 22022600