Anti-Hsp104 抗体

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

'Hsp104' assists in the maintenance and repair of cellular proteins under stress conditions. It is not usually part of larger complexes; instead it functions as a hexameric ring forming a powerful disaggregase. By refolding aggregated proteins 'Hsp104' enables the cell to maintain proteostasis and environmental adaptability. This activity is critical in organisms facing stressful environments allowing for survival under extreme conditions that could otherwise be fatal due to protein aggregation.

Pathways

'Hsp104' is involved in the protein quality control and stress response pathways. Its role in these pathways is important for cellular homeostasis and survival during heat shock or oxidative stress. 'Hsp104' interacts with other molecular chaperones like Hsp70 and Hsp40 which help in the initial binding and targeting of protein aggregates to 'Hsp104'. These interactions facilitate a coordinated response that ultimately leads to the restoration of cellular protein functionality.