AB38905

HRP Anti-Plasmodium aldolase 抗体

Name: HRP Anti-Plasmodium aldolase 抗体 (ab38905) | Abcam
Brand: Abcam Limited
SKU: AB38905
Price: 76000 JPY
Availability: InStock
Rating: 5 (1 reviews)

HRP Anti-Plasmodium aldolase antibody

(1 Review)

(26 Publications)

Rabbit Polyclonal ALF antibody - conjugated to HRP. Suitable for ELISA, WB and reacts with Plasmodium falciparum samples. Cited in 26 publications.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

標識

HRP

励起波長/蛍光波長

キャリアフリー

交差種

Plasmodium falciparum

アプリケーション

WB, ELISA

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Plasmodium falciparum": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 1.19% HEPES, 0.58% Sodium chloride, 0.2% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Plasmodium aldolase also known as ALD or aldolase MW is an important enzyme in the glycolytic pathway. It has a molecular weight of approximately 39 kDa. The enzyme catalyzes the reversible cleavage of fructose-16-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. This reaction is important for energy production in the parasite Plasmodium which causes malaria. Plasmodium aldolase is expressed in various stages of the parasite's life cycle including the erythrocytic stage where the parasite infects red blood cells.

Biological function summary

Plasmodium aldolase plays a significant role in the survival and replication of the malaria parasite. It is not part of a larger protein complex but often associates with the cytoskeleton within the parasite facilitating its structural integrity and mobility. The enzyme's activity directly impacts the energy metabolism of Plasmodium making it essential for parasite survival and development in the host.

Pathways

Enzymes like Plasmodium aldolase operate within glycolytic and gluconeogenic pathways which are central to carbohydrate metabolism. In the glycolytic pathway aldolase sequentially interacts with proteins such as glyceraldehyde-3-phosphate dehydrogenase. Through its function in energy production aldolase indirectly supports various biosynthetic reactions and parasitic replication processes specific to Plasmodium.

Disturbances in Plasmodium aldolase function are directly linked to malaria one of the major global infectious diseases. The enzyme itself is a target for antimalarial drug development as inhibitors could potentially disrupt parasite energy metabolism leading to its death. Research also indicates a connection between aldolase and another protein lactate dehydrogenase which facilitates the parasite's anaerobic metabolism thereby contributing to its adaptability under different oxygen conditions in the human host.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information Plasmodium aldolase

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文献 (26)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:142 PubMed39880906

2025

Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization.

Applications

Unspecified application

Species

Unspecified reactive species

Junpei Fukumoto,Minako Yoshida,Suzumi M Tokuoka,Eri Saki H Hayakawa,Shinya Miyazaki,Takaya Sakura,Daniel Ken Inaoka,Kiyoshi Kita,Jiro Usukura,Hideo Shindou,Fuyuki Tokumasu

Proceedings of the National Academy of Sciences of the United States of America 122:e2403689122 PubMed39773028

2025

Mutational analysis of an antimalarial drug target, ATP4.

Applications

Unspecified application

Species

Unspecified reactive species

Swaksha Rachuri,Binod Nepal,Anurag Shukla,Aarti Ramanathan,Joanne M Morrisey,Thomas Daly,Michael W Mather,Lawrence W Bergman,Sandhya Kortagere,Akhil B Vaidya

eLife 13: PubMed38921824

2024

RNA polymerase III is involved in regulating virulence.

Applications

Unspecified application

Species

Unspecified reactive species

Gretchen Diffendall,Aurelie Claes,Anna Barcons-Simon,Prince Nyarko,Florent Dingli,Miguel M Santos,Damarys Loew,Antoine Claessens,Artur Scherf

iScience 27:109760 PubMed38726364

2024

M--M mediated denaturation resistant P2 tetramer on the infected erythrocyte surface of malaria parasite imports serum fatty acids.

Applications

Unspecified application

Species

Unspecified reactive species

Sudipta Das,Anwesa Manna,Oindrila Majumdar,Lena Dhara

Pharmaceutics 15: PubMed37896200

2023

Epidrugs as Promising Tools to Eliminate Artemisinin-Resistant and Quiescent Parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Thibaud Reyser,Lucie Paloque,Michel Nguyen,Jean-Michel Augereau,Matthew John Fuchter,Marie Lopez,Paola B Arimondo,Storm Hassell-Hart,John Spencer,Luisa Di Stefano,Françoise Benoit-Vical

ACS infectious diseases 9:1257-1266 PubMed37216290

2023

Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Irina Dobrescu,Elie Hammam,Jerzy M Dziekan,Aurélie Claës,Ludovic Halby,Peter Preiser,Zbynek Bozdech,Paola B Arimondo,Artur Scherf,Flore Nardella

Nature 612:528-533 PubMed36477538

2022

A transcriptional switch controls sex determination in Plasmodium falciparum.

Applications

Unspecified application

Species

Unspecified reactive species

A R Gomes,A Marin-Menendez,S H Adjalley,C Bardy,C Cassan,M C S Lee,A M Talman

Life science alliance 6: PubMed36379669

2022

Discovery of RUF6 ncRNA-interacting proteins involved in immune evasion.

Applications

Unspecified application

Species

Unspecified reactive species

Gretchen M Diffendall,Anna Barcons-Simon,Sebastian Baumgarten,Florent Dingli,Damarys Loew,Artur Scherf

PLoS pathogens 18:e1010887 PubMed36223427

2022

Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy James Russell,Erandi K De Silva,Valerie M Crowley,Kathryn Shaw-Saliba,Namita Dube,Gabrielle Josling,Charisse Flerida A Pasaje,Irene Kouskoumvekaki,Gianni Panagiotou,Jacquin C Niles,Marcelo Jacobs-Lorena,C Denise Okafor,Francisco-Javier Gamo,Manuel Llinás

Journal of medicinal chemistry 64:10403-10417 PubMed34185525

2021

Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites.

Applications

Unspecified application

Species

Unspecified reactive species

Flore Nardella,Ludovic Halby,Irina Dobrescu,Johanna Viluma,Corentin Bon,Aurélie Claes,Véronique Cadet-Daniel,Ambre Tafit,Camille Roesch,Elie Hammam,Diane Erdmann,Melissa Mairet-Khedim,Roger Peronet,Salah Mecheri,Benoit Witkowski,Artur Scherf,Paola B Arimondo

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

HRP Anti-Plasmodium aldolase 抗体

HRP Anti-Plasmodium aldolase antibody

Key facts

宿主種

クローン性

アイソタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (26)

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Abcam product promise