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AB195193

HRP Anti-Mannose Receptor 抗体 [EPR6828(B)]

HRP Anti-Mannose Receptor antibody [EPR6828(B)]

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(1 Publication)

Rabbit Recombinant Monoclonal Mannose Receptor antibody - conjugated to HRP. Suitable for WB and reacts with Human samples. Cited in 1 publication.

別名を表示する

CD206, CLEC13D, CLEC13DL, MRC1L1, MRC1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, Macrophage mannose receptor 1-like protein 1, hMR

1 Images
Western blot - HRP Anti-Mannose Receptor antibody [EPR6828(B)] (AB195193)
  • WB

Lab

Western blot - HRP Anti-Mannose Receptor antibody [EPR6828(B)] (AB195193)

Blocking buffer : 3% Milk Gel type : TA

All lanes:

Western blot - HRP Anti-Mannose Receptor antibody [EPR6828(B)] (ab195193) at 1/5000 dilution

All lanes:

Human Lung Tissue Lysate at 10 µg

Predicted band size: 166 kDa

Observed band size: 200 kDa

false

Exposure time: 20min

関連する標識済み抗体及び組成の異なる製品 (3)

  • Unconjugated

    Anti-Mannose Receptor antibody [EPR6828(B)]

  • Carrier free

    Anti-Mannose Receptor antibody [EPR6828(B)] - BSA and Azide free

  • Carrier free

    Anti-Mannose Receptor antibody [EPR6828(B)] - Low endotoxin, Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR6828(B)

アイソタイプ

IgG

標識

HRP

励起波長/蛍光波長
キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000", "WB-species-notes": "<p></p>" } } }
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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.1% Proclin 300 Solution Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Mannose Receptor also known as CD206 or MRC1 is a type of C-type lectin receptor with a molecular weight of 175 kDa. It is expressed on the surface of macrophages and dendritic cells. This receptor binds to complex carbohydrates like mannose and fucose found on pathogen surfaces playing an important role in their recognition. Mannose Receptors act as endocytic receptors aiding in the internalization and degradation of pathogens.
Biological function summary

The Mannose Receptor functions in pathogen recognition and clearance by binding to specific carbohydrates on the pathogen's surface. It is not part of a larger molecular complex but works independently to facilitate phagocytosis. The receptor is essential in immune responses allowing macrophages and dendritic cells to efficiently capture and process antigens for presentation to T cells. This enables the initiation of adaptive immune responses.

Pathways

Researchers know that the Mannose Receptor plays an important role in immune signaling pathways particularly in antigen processing and presentation. It interacts with proteins involved in these pathways including those necessary for the internalization and degradation of bound antigens. Moreover it works alongside scavenger receptors contributing to the regulation of immune and inflammatory responses.

The Mannose Receptor is often linked to pulmonary tuberculosis and certain types of cancer. When macrophages express this receptor it can modulate immune responses against Mycobacterium tuberculosis by aiding in its recognition. In cancer altered expression of CD206 can indicate tumor-associated macrophages which promote tumor growth by suppressing immune responses. These connections highlight the receptor's potential as a diagnostic marker and therapeutic target.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.. (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.. (Microbial infection) Interacts with Hepatitis B virus envelope protein.
See full target information MRC1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Clinical proteomics 16:34 PubMed31467500

2019

Potential early clinical stage colorectal cancer diagnosis using a proteomics blood test panel.

Applications

Unspecified application

Species

Unspecified reactive species

Seong Beom Ahn,Samridhi Sharma,Abidali Mohamedali,Sadia Mahboob,William J Redmond,Dana Pascovici,Jemma X Wu,Thiri Zaw,Subash Adhikari,Vineet Vaibhav,Edouard C Nice,Mark S Baker
View all publications
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代替製品

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AB64693

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Primary Antibodies

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組合せ製品

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Primary Antibodies

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Primary Antibodies

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Abcam product promise

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