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AB46527

HRP Anti-Kappa light chain 抗体

HRP Anti-Kappa light chain antibody

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Goat Polyclonal IGKC antibody - conjugated to HRP. Suitable for ELISA, WB, IHC-Fr and reacts with Mouse samples. Immunogen corresponding to Full Length Protein corresponding to Mouse Igkc.

別名を表示する

Immunoglobulin kappa constant, Ig kappa chain C region MOPC 21, Igkc

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

標識

HRP

励起波長/蛍光波長
キャリアフリー

No

交差種

Mouse

アプリケーション

ELISA, WB, IHC-Fr

applications

免疫原

Full Length Protein corresponding to Mouse Igkc. The exact immunogen used to generate this antibody is proprietary information.

P01837

特異性

This antibody recognises mouse kappa light chains; both bound and free.

Reactivity data

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
This antibody was made from pooled antisera from goats immunised with mouse paraproteins bearing kappa light chains. Antiserum was purified by affinity chromatography on pooled mouse Igs with kappa light chains. The antiserum was cross adsorbed on pooled mouse Igs with lambda light chains.
バッファー組成
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
長期保存温度
+4°C

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The kappa light chain alternatively known as Ig kappa chain is a component of immunoglobulins which are important for immune response. This protein has a molecular mass of roughly 25 kDa. It predominantly expresses in B lymphocytes where it pairs with heavy chains to form antibodies. Its expression is indicative of mature B cell functions serving as a marker for certain types of immune cells. The kappa light chain can also be detected outside of cells circulating in the blood and other bodily fluids.
Biological function summary

Kappa light chains are integral to the structure and function of antibodies. As part of the immunoglobulin molecule these chains contribute to antigen specificity by combining with heavy chains. Together they form the antigen-binding site. The kappa light chain is not part of a multiprotein complex; rather it directly participates in the antibody response. The presence of either kappa or lambda light chains can determine the particularities of antibody characteristics.

Pathways

Kappa light chains are elements of the immunological pathways notably the adaptive immune response. They interact with other proteins like immunoglobulin heavy chains to neutralize pathogens. The constant region of the kappa chain plays a role in determining the isotype of immunoglobulins which affects how antibodies mediate immune effector functions. Cross-linking of surface immunoglobulin by antigens can trigger B cell activation an essential step in the adaptive immune system.

Kappa light chains associate closely with multiple myeloma and certain types of lymphomas. Overproduction of kappa light chains in these diseases results in high levels detectable in the serum or urine which can be used diagnostically as markers. Also dysregulation of kappa chains correlates with autoimmune disorders whereby the immune system incorrectly targets its tissues. In disorders like these the interplay between kappa and lambda chains often arises showing imbalance between the two as a sign of abnormal B cell activity.

製品プロトコール

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ターゲットの情報

See full target information Igkc

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