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AB24462

HRP Anti-C Reactive Protein 抗体 [C6]

HRP Anti-C Reactive Protein antibody [C6]

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(4 Publications)

Mouse Monoclonal C Reactive Protein antibody C6. Suitable for ELISA, sELISA and reacts with Human samples. Cited in 4 publications.

別名を表示する

PTX1, CRP, C-reactive protein

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

C6

アイソタイプ

IgG2a

標識

HRP

励起波長/蛍光波長
キャリアフリー

No

交差種

Human

アプリケーション

sELISA, ELISA

applications

免疫原

Native Full Length Protein corresponding to Human CRP.

P02741

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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製品の詳細

Specific antibody titer in ELISA is > 10-6.
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.05% Proclin 300 Constituents: 0.8% Sodium chloride, 0.18% Disodium hydrogenorthophosphate, 0.024% Potassium phosphate monobasic, 0.02% Potassium chloride
出荷温度
Blue Ice
長期保存温度
+4°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

C-reactive protein (CRP) also known as CRP protein is an acute-phase protein with a molecular mass of approximately 25 kDa. It is primarily synthesized in the liver in response to cytokines. This protein appears in the blood where it binds to phosphocholine expressed on the surface of dead or dying cells. CRP is often used as a biomarker for inflammation in the body and its levels in human and canine (anti CRP used) blood samples are measured using assays like the CRP ELISA test or CRP ELISA kit.
Biological function summary

CRP plays a significant role in the innate immune system by recognizing foreign pathogens and damaged cells. It does not form part of a larger complex but itself can bind to specific ligands initiating the complement cascade. This activation enhances phagocytosis by macrophages contributing to the clearance of necrotic and apoptotic cells. The CRP protein therefore acts as a fast responder in the presence of inflammation making it a useful indicator for monitoring inflammatory diseases.

Pathways

CRP operates predominantly within the acute-phase response pathway. Its production is upregulated by cytokines such as IL-6 which connects it to inflammation-signaling pathways. CRP also interacts with the complement system bridging innate and adaptive immunity. Besides CRP could indirectly influence pathways involving other inflammatory proteins like serum amyloid A and haptoglobin creating a network of responses important for managing inflammation.

Elevated CRP levels are commonly associated with cardiovascular diseases and rheumatoid arthritis. In cardiovascular diseases CRP acts as a marker for atherosclerosis where the protein levels correlate with disease severity. It connects with other proteins involved in inflammatory processes such as fibrinogen to contribute to disease pathology. In rheumatoid arthritis CRP provides insights into disease activity helping in the assessment of treatment responses.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Displays several functions associated with host defense : it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
See full target information CRP
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Osteoarthritis and cartilage 26:255-263 PubMed29128509

2017

Monocyte activation is elevated in women with knee-osteoarthritis and associated with inflammation, BMI and pain.

Applications

Unspecified application

Species

Unspecified reactive species

D Loukov,S Karampatos,M R Maly,D M E Bowdish

Experimental gerontology 105:47-52 PubMed29032243

2017

DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly.

Applications

sELISA

Species

Unspecified reactive species

Chris P Verschoor,Lisa M McEwen,Michael S Kobor,Mark B Loeb,Dawn M E Bowdish

The Journal of infectious diseases 216:191-197 PubMed28838148

2017

Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents.

Applications

Unspecified application

Species

Unspecified reactive species

Chris P Verschoor,Alina Lelic,Robin Parsons,Carole Evelegh,Jonathan L Bramson,Jennie Johnstone,Mark B Loeb,Dawn M E Bowdish

Journal of immunological methods 336:78-84 PubMed18495149

2008

Effects of blood sample handling procedures on measurable inflammatory markers in plasma, serum and dried blood spot samples.

Applications

Unspecified application

Species

Unspecified reactive species

Kristin Skogstrand,Charlotte K Ekelund,Poul Thorsen,Ida Vogel,Bo Jacobsson,Bent Nørgaard-Pedersen,David M Hougaard
View all publications
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代替製品

Primary Antibodies

AB51016

Anti-C Reactive Protein antibody [EPR283Y]

RabMAb|Recombinant

Western blot - Anti-C Reactive Protein antibody [EPR283Y] (AB51016)

  • 0
  • 0
Primary Antibodies

AB32412

Anti-C Reactive Protein antibody [Y284]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C Reactive Protein antibody [Y284] (AB32412)

  • 5
  • 6
Primary Antibodies

AB157242

Anti-C Reactive Protein antibody [Y284] - Low endotoxin, Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C Reactive Protein antibody [Y284] - Low endotoxin, Azide free (AB157242)

  • 0
  • 0
Primary Antibodies

AB271830

Anti-C Reactive Protein antibody [Y284] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C Reactive Protein antibody [Y284] - BSA and Azide free (AB271830)

  • 0
  • 0
Primary Antibodies

AB207756

Anti-C Reactive Protein antibody [EPR20063]

RabMAb|Recombinant

Western blot - Anti-C Reactive Protein antibody [EPR20063] (AB207756)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB6655

Biotin Anti-Fluorescein antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-Fluorescein antibody (AB6655)

  • 0
  • 0
Proteins & Peptides

AB283925

Recombinant Human C-Reactive Protein/CRP Protein

SDS-PAGE - Recombinant Human C-Reactive Protein/CRP Protein (AB283925)

  • 0
  • 0
Primary Antibodies

AB185558

Anti-CRP-1 antibody [EPR14345-43]

RabMAb|Recombinant

Western blot - Anti-CRP-1 antibody [EPR14345-43] (AB185558)

  • 0
  • 0
Primary Antibodies

AB196458

Alexa Fluor® 488 Anti-C3 antibody [EPR2988]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-C3 antibody [EPR2988] (AB196458)

  • 0
  • 0

Abcam product promise

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