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AB230697

Anti-HOXD12 抗体 - C-terminal

Anti-HOXD12 antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal HOXD12 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HOXD12 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

HOX4H, HOXD12, Homeobox protein Hox-D12, Homeobox protein Hox-4H

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXD12 antibody - C-terminal (AB230697)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HOXD12 antibody - C-terminal (AB230697)

Formalin-fixed, paraffin-embedded human liver tissue stained for HOXD12 using ab230697 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-HOXD12 antibody - C-terminal (AB230697)
  • WB

Supplier Data

Western blot - Anti-HOXD12 antibody - C-terminal (AB230697)

All lanes:

Western blot - Anti-HOXD12 antibody - C-terminal (ab230697) at 1/500 dilution

Lane 1:

A549 (human lung carcinoma cell line) whole cell lysate

Lane 2:

HUVEC (human umbilical vein endothelial cell line) whole cell lysate

Lane 3:

NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate

Predicted band size: 29 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human HOXD12 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P35452

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組合せ製品

Primary Antibodies

AB151575

Anti-HoxC6 antibody [EPR7922(2)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-HoxC6 antibody [EPR7922(2)] (AB151575)

  • 0
  • 0
Primary Antibodies

AB229234

Anti-HOXD13 antibody

Western blot - Anti-HOXD13 antibody (AB229234)

  • 0
  • 0
Primary Antibodies

AB9374

Anti-AACT antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AACT antibody (AB9374)

  • 0
  • 0
Primary Antibodies

AB106238

Anti-RNA silencing suppressor p19 antibody

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.3 Preservative: 0.01% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

HOXD12 also known as Homeobox D12 is a transcription factor with a molecular mass of about 40 kDa. The HOXD12 protein plays a role in regulating gene expression during embryonic development and tissue differentiation. It belongs to the homeobox gene family which is characterized by a conserved DNA sequence. HOXD12 is primarily expressed in the limbs and other tissues during embryogenesis and contributes to proper limb formation.
Biological function summary

Members of the homeobox gene family including HOXD12 act as master regulators of development. HOXD12 functions in a complex network to ensure the correct spatial and temporal expression of genes necessary for development. It is important for pattern formation in limbs and digits. The interaction of HOXD12 with other HOX proteins is essential for its role in conferring positional identity during embryonic development.

Pathways

HOXD12 takes part in the developmental pathways that involve limb patterning and organogenesis. One significant pathway includes the regulation of anterior-posterior axis development. Within this pathway HOXD12 interacts with other HOX genes like HOXA11 and HOXB13 to orchestrate intricate developmental processes. The involvement of HOXD12 in these pathways ensures the accurate execution of developmental programs.

Mutations or misregulation of HOXD12 correlate with congenital limb malformations such as synpolydactyly which involves extra and fused fingers or toes. HOXD12 may also have connections to skeletal disorders through its function in limb development. It interacts with other gene products such as those from HOXD13 which when mutated also result in similar limb deformities. Understanding the role of HOXD12 in these conditions aids in the study of developmental abnormalities.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXD12
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

iMeta 4:e70037 PubMed40860437

2025

Maternal gut microbiota-derived daidzein prevents osteoporosis in female offspring following prenatal prednisone exposure.

Applications

Unspecified application

Species

Unspecified reactive species

Chi Ma,Hangyuan He,Kunpeng Wang,Juanjuan Guo,Liang Liu,Yuting Chen,Bin Li,Hao Xiao,Xufeng Li,Xiaoqian Lu,Tingting Wang,Yinxian Wen,Hui Wang,Liaobin Chen

Science advances 9:eade9459 PubMed36662852

2023

Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in -associated retinitis pigmentosa.

Applications

Unspecified application

Species

Unspecified reactive species

Maria E Mercau,Yemsratch T Akalu,Francesca Mazzoni,Gavin Gyimesi,Emily J Alberto,Yong Kong,Brian P Hafler,Silvia C Finnemann,Carla V Rothlin,Sourav Ghosh
View all publications
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Abcam product promise

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