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AB50839

Anti-HOXC9 抗体 [HOXCA6E6]

Anti-HOXC9 antibody [HOXCA6E6]

5

(5 Reviews)

|

(11 Publications)

Mouse Monoclonal HOXC9 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HOXC9.

別名を表示する

HOX3B, HOXC9, Homeobox protein Hox-C9, Homeobox protein Hox-3B

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)

ab50839 at a 1/5 dilution staining HOXC9 in Hela cells using Alexa Fluor® 488 Goat Anti-mouse IgG at a 1/200 dilution.

Western blot - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)
  • WB

Unknown

Western blot - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)

All lanes:

Western blot - Anti-HOXC9 antibody [HOXCA6E6] (ab50839) at 1/100 dilution

All lanes:

HT-1080 whole cell lysate at 50 µg

Secondary

All lanes:

Mouse IgG antibody at 1/2500 dilution

Predicted band size: 29 kDa

Observed band size: 29 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

HOXCA6E6

アイソタイプ

IgG2b

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF, WB

applications

免疫原

Recombinant Fragment Protein within Human HOXC9. The exact immunogen used to generate this antibody is proprietary information.

P31274

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/5", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
purified from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (~95%) fetal bovine serum, filtered through a 0.22µm membrane.
バッファー組成
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

HOXC9 also known as Homeobox C9 is a transcription factor that belongs to the homeobox family specifically the HOX gene cluster. It regulates gene expression by binding to specific DNA sequences. The protein has a molecular mass of about 28 kDa. HOXC9 is expressed in various tissues including the nervous system particularly during embryonic development. It plays an important role in patterning the anterior-posterior axis and the development of specific body structures.
Biological function summary

Genes that HOXC9 regulates play key roles in developmental processes such as neural differentiation and limb formation. HOXC9 might operate as part of a larger transcriptional complex that involves other HOX proteins allowing precise control over developmental gene expression. The protein ensures that cells at different developmental stages respond correctly to morphogenetic signals facilitating proper organismal formation.

Pathways

HOXC9 actively participates in the retinoic acid signaling pathway important for neurodevelopmental regulation. This pathway requires a balance between HOXC9 and Receptor Interacting Protein 1 (RIP1) for correct gene expression. Another critical pathway is the Wnt signaling pathway where HOXC9 interacts with components such as beta-catenin to further modulate gene transcription related to cell fate decisions.

Research links HOXC9 dysregulation to neurodevelopmental disorders and certain cancers like leukemia. Abnormal HOXC9 expression disrupts regular neural development and contributes to malignancy. Its interaction with proteins including members of the Polycomb group like Bmi1 influences these pathologies. Understanding HOXC9's involvement helps in devising therapeutic strategies for these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXC9
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文献 (11)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:105898 PubMed36647382

2023

Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Xue,Bo Li,Huihui Liu,Yujie Xiao,Bo Li,Lei Ren,Huijuan Li,Zhicheng Shao

eLife 11: PubMed36154671

2022

Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor.

Applications

Unspecified application

Species

Unspecified reactive species

Antigoni Gogolou,Celine Souilhol,Ilaria Granata,Filip J Wymeersch,Ichcha Manipur,Matthew Wind,Thomas J R Frith,Maria Guarini,Alessandro Bertero,Christoph Bock,Florian Halbritter,Minoru Takasato,Mario R Guarracino,Anestis Tsakiridis

Current protocols 1:e244 PubMed34547185

2021

In Vitro Generation of Posterior Motor Neurons from Human Pluripotent Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Matt Wind,Anestis Tsakiridis

Cell stem cell 26:172-186.e6 PubMed31956040

2020

Self-Organizing 3D Human Trunk Neuromuscular Organoids.

Applications

Unspecified application

Species

Unspecified reactive species

Jorge-Miguel Faustino Martins,Cornelius Fischer,Alessia Urzi,Ramon Vidal,Severine Kunz,Pierre-Louis Ruffault,Loreen Kabuss,Iris Hube,Elisabeta Gazzerro,Carmen Birchmeier,Simone Spuler,Sascha Sauer,Mina Gouti

PloS one 14:e0218269 PubMed31188873

2019

Prediction of neuroblastoma cell response to treatment with natural or synthetic retinoids using selected protein biomarkers.

Applications

Unspecified application

Species

Unspecified reactive species

Viera Dobrotkova,Petr Chlapek,Marta Jezova,Katerina Adamkova,Pavel Mazanek,Jaroslav Sterba,Renata Veselska

Current protocols in stem cell biology 49:e81 PubMed30688409

2019

Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas J R Frith,Anestis Tsakiridis

Development (Cambridge, England) 145: PubMed30337375

2018

Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Justin K Ichida,Kim A Staats,Brandi N Davis-Dusenbery,Kendell Clement,Kate E Galloway,Kimberly N Babos,Yingxiao Shi,Esther Y Son,Evangelos Kiskinis,Nicholas Atwater,Hongcang Gu,Andreas Gnirke,Alexander Meissner,Kevin Eggan

eLife 7: PubMed30095409

2018

Human axial progenitors generate trunk neural crest cells in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Thomas Jr Frith,Ilaria Granata,Matthew Wind,Erin Stout,Oliver Thompson,Katrin Neumann,Dylan Stavish,Paul R Heath,Daniel Ortmann,James Os Hackland,Konstantinos Anastassiadis,Mina Gouti,James Briscoe,Valerie Wilson,Stuart L Johnson,Marysia Placzek,Mario R Guarracino,Peter W Andrews,Anestis Tsakiridis

PloS one 8:e58311 PubMed23484014

2013

HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra J Stoll,Susanne Bartsch,Jens Kroll

Circulation research 108:1367-77 PubMed21493894

2011

The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra J Stoll,Susanne Bartsch,Hellmut G Augustin,Jens Kroll
View all publications
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Abcam product promise

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