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AB227879

Anti-HOXB13 抗体

Anti-HOXB13 antibody

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(1 Publication)

Rabbit Polyclonal HOXB13 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HOXB13.

別名を表示する

Homeobox protein Hox-B13, HOXB13

2 Images
Immunoprecipitation - Anti-HOXB13 antibody (AB227879)
  • IP

Supplier Data

Immunoprecipitation - Anti-HOXB13 antibody (AB227879)

HOXB13 was immunoprecipitated from PC-3 (human prostate adenocarcinoma cell line) nuclear extract with 5 μg ab227879. Western blot was performed from the immunoprecipitate using ab227879. Anti-Rabbit IgG was used as a secondary reagent.

Lane 1 : PC-3 nuclear extract (Input).

Lane 2 : Control IgG IP in PC-3 nuclear extract.

Lane 3 : ab227879 IP in PC-3 nuclear extract.

All lanes:

Immunoprecipitation - Anti-HOXB13 antibody (ab227879)

Predicted band size: 30 kDa

false

Western blot - Anti-HOXB13 antibody (AB227879)
  • WB

Supplier Data

Western blot - Anti-HOXB13 antibody (AB227879)

12 % SDS-PAGE gel.

All lanes:

Western blot - Anti-HOXB13 antibody (ab227879) at 1/1000 dilution

Lane 1:

PC-3 (human prostate adenocarcinoma cell line) whole cell extract at 30 µg

Lane 2:

PC-3 (human prostate adenocarcinoma cell line) nuclear extract at 30 µg

Predicted band size: 30 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IP

applications

免疫原

Recombinant Fragment Protein within Human HOXB13. The exact immunogen used to generate this antibody is proprietary information.

Q92826

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/100 - 1/500", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

HOXB13 also known as Homeobox protein Hox-B13 is a transcription factor with an important role in gene regulation. It weighs around 30 kDa. HOXB13 is part of the homeobox gene family which means it contains a DNA-binding domain known as the homeodomain. HOXB13 primarily expresses in the prostate skin and parts of the intestine. In these tissues it regulates specific genes that drive cellular development and differentiation processes.
Biological function summary

HOXB13 guides tissue patterning and morphological development. It functions within a group of proteins forming transcriptional regulatory complexes. This protein influences cellular differentiation especially in the prostate and plays a part in epidermal development. HOXB13's regulatory functions extend to several genes that define cell fate and organogenesis contributing significantly to tissue-specific function.

Pathways

HOXB13 interacts heavily within the Wnt signaling pathway which is key for cell proliferation and differentiation. It also interfaces with the androgen receptor signaling pathway. HOXB13 modulates genes influenced by androgen signaling thereby impacting cell growth and differentiation in the prostate. Moreover its interaction with proteins such as β-catenin within the Wnt pathway highlights its involvement in cell development and communication.

HOXB13 has associations with prostate cancer and colorectal cancer. Mutations or dysregulation of HOXB13 can alter normal cellular behavior leading to malignancies in these tissues. In prostate cancer HOXB13 can interact with other proteins like the androgen receptor that drive tumor progression through aberrant signaling. In colorectal cancer HOXB13's role in gene regulation can lead to disrupted cellular homeostasis when mutated contributing to tumorigenesis.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed : 28473536).
See full target information HOXB13
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:23065 PubMed40595270

2025

Clinical significance of TAM receptor in the minor salivary glands of patients with Sjögren's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Sung-Eun Choi,Ji-Hyoun Kang,Dong-Jin Park,Nah Ihm Kim,Ji Shin Lee,Kyung Chul Yoon,Shin-Seok Lee
View all publications
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代替製品

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AB201682

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Primary Antibodies

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Primary Antibodies

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  • 0
  • 0

組合せ製品

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Primary Antibodies

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