AB168179

Anti-HOXA1 抗体

Name: Anti-HOXA1 抗体 (ab168179) | Abcam
Brand: Abcam Limited
SKU: AB168179
Price: 76000 JPY
Availability: InStock

Anti-HOXA1 antibody

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(4 Publications)

Mouse Polyclonal HOXA1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human HOXA1.

別名を表示する

HOX1F, HOXA1, Homeobox protein Hox-A1, Homeobox protein Hox-1F

2 Images

Immunocytochemistry/ Immunofluorescence - Anti-HOXA1 antibody (AB168179)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-HOXA1 antibody (AB168179)

Immunofluorescent analysis of HeLa cells labeling HOXA1 with ab168179 at 10 µg/ml.

Unknown

Western blot - Anti-HOXA1 antibody (AB168179)

All lanes:

Western blot - Anti-HOXA1 antibody (ab168179) at 1 µg/mL

Lane 1:

HOXA1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat anti-Mouse IgG HRP at 1/2500 dilution

Predicted band size: 36 kDa

false

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

WB, ICC/IF

applications

免疫原

Recombinant Full Length Protein corresponding to Human HOXA1.

P49639

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

HOXA1 also known as homeobox protein Hox-A1 is a transcription factor composed of 36 kDa. It contains a conserved DNA-binding domain known as the homeodomain. HOXA1 is encoded by the HOXA1 gene part of the Hox gene family responsible for regulating gene expression during early embryonic development. It gets expressed in specific regions during various developmental stages particularly contributing to the formation of the hindbrain and spinal cord. HOXA1 plays a significant role in controlling morphogenesis and differentiation processes.

Biological function summary

The transcription factor regulates critical developmental processes by influencing the expression of genes involved in anterior-posterior patterning. HOXA1 functions within a complex involving other HOX proteins ensuring precise spatial and temporal gene regulation during development. This regulation facilitates the establishment of distinct body structures and organ systems as the embryo progresses. HOXA1 participates in defining boundaries and segmental structures in embryonic tissues.

Pathways

HOXA1 impacts the retinoic acid signaling pathway and the Notch signaling pathway. It plays a significant role in the retinoic acid signaling axis influencing cell differentiation by modulating retinoid-responsive elements. In the Notch signaling pathway HOXA1 interacts with genes that control cell fate decisions often working in concert with other HOX proteins like HOXB1 and HOXD1. This involves activating downstream effectors vital for embryonic patterning and neurogenesis.

Researchers have linked HOXA1 dysregulation to certain congenital defects and cancers. It associates with congenital conditions such as Bosley-Salih-Alorainy syndrome characterized by abnormalities in facial and cranial nerves alongside problems with hearing and cardiovascular development. In cancer aberrant HOXA1 expression has been observed linking to breast cancer progression hinting at its involvement in tumorigenesis. These connections often involve interactions with proteins such as PAX1 in congenital abnormalities and ERBB2 in cancer highlighting the need for therapeutic explorations targeting these pathways.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed : 16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).

See full target information HOXA1

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:14515 PubMed40280985

2025

BPIFB4 rs4339026 A > G polymorphism impacts COPD susceptibility in the Kashi population, China.

Applications

Unspecified application

Species

Unspecified reactive species

Jingran Xu,Li Tao,Yanyan Shi,Hui Gong,Zulipikaer Abudureheman,Aifang Zheng,Xuemei Zhong,Lexin Xue,Xiaoguang Zou,Li Li

European journal of clinical investigation 51:e13487 PubMed33410156

2021

CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Pengfei Lyu,Zhensheng Zhai,Zhengwen Hao,Haoruo Zhang,Jiefeng He

RNA biology 17:1613-1624 PubMed32372724

2020

Role of PIWI-like 4 in modulating neuronal differentiation from human embryonal carcinoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Charannya Sozheesvari Subhramanyam,Qiong Cao,Cheng Wang,Zealyn Shi Lin Heng,Zhihong Zhou,Qidong Hu

Molecular medicine reports 19:1875-1882 PubMed30628697

2019

microRNA‑577 inhibits cell proliferation and invasion in non‑small cell lung cancer by directly targeting homeobox A1.

Applications

Unspecified application

Species

Unspecified reactive species

Lan Men,Dandan Nie,Haiying Nie

View all publications

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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。

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Anti-HOXA1 抗体

Anti-HOXA1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-HOXA1 antibody (AB168179)

Western blot - Anti-HOXA1 antibody (AB168179)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

代替製品

Primary Antibodies

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise