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AB28204

Anti-HODE 抗体

Anti-HODE antibody

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(1 Publication)

Goat Polyclonal HODE antibody. Suitable for ELISA, RIA and reacts with Chemical samples. Cited in 1 publication. Immunogen corresponding to Chemical / Small Molecule corresponding to HODE.

別名を表示する

13 HODE, 13 Hydroxyoctadecadienoic acid, 13 S HODE, 13 S hydroxyoctadecadienoic acid, 9 HODE, 9 hydroxyoctadecadienoic acid, Hydroxyoctadecadienoic Acid

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

アプリケーション

ELISA, RIA

applications

特異性

REACTIVITY: HAPTEN REACTIVITY 9(±)-HODE 100.0% 9(S)-HODE 100.0% 9(R)-HODE 100.0% 13(S)-HODE 1.2% 13(R)-HODE 1.2% 9-oxo-ODE 1.2% 13-oxo-ODE 2.4% 11(S)-HETE 0.0% 15(S)-HETE 0.0% Linoleic Acid 0.0%

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製に関する特記事項
Ammonium sulphate fractionation.
バッファー組成
Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-80°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The biological target HODE which includes both 13-HODE and 9-HODE refers to hydroxyoctadecadienoic acids. These are oxidized derivatives of linoleic acid. HODEs have a molecular mass around 296.4 g/mol and are found throughout various tissues in the body including the cellular membranes of inflammatory cells and tissues involved in lipid metabolism. They play key roles in oxidative stress responses and are expressed in cells where lipoxygenase enzymes operate converting linoleic acid to HODE.
Biological function summary

Hydroxyoctadecadienoic acids serve as signaling molecules. They are involved in modulating inflammatory responses and maintaining cellular homeostasis. HODEs do not form part of a classical protein complex but interact with various receptors and enzymes to execute their biological function. They contribute to cell signaling pathways that regulate the body's response to cellular damage and inflammation.

Pathways

HODEs participate in the arachidonic acid metabolism pathway. This pathway involves important enzymes like 15-lipoxygenase which catalyzes the oxidation of linoleic acid to form HODEs. This process influences the production of other signaling molecules like leukotrienes and prostaglandins which are critical for inflammatory response regulation. HODEs also interact with peroxisome proliferator-activated receptors (PPARs) therefore influencing fatty acid metabolism and energy homeostasis.

HODEs are implicated in the development of atherosclerosis. They contribute to the formation of oxidized low-density lipoproteins (oxLDL) which are key in the pathogenesis of this cardiovascular disease. Additionally their involvement in inflammation connects HODEs to conditions like rheumatoid arthritis. In these disorders HODEs interact with proteins such as C-reactive protein and tumor necrosis factor-alpha (TNF-alpha) which are important in orchestrating inflammatory and immune responses.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information HODE
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed35409374

2022

Ionizing Radiation Induces Disc Annulus Fibrosus Senescence and Matrix Catabolism via MMP-Mediated Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Jiongbiao Zhong,Joseph Chen,Anthony A Oyekan,Michael W Epperly,Joel S Greenberger,Joon Y Lee,Gwendolyn A Sowa,Nam V Vo
View all publications
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組合せ製品

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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