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AB218037

Anti-HES6 抗体

Anti-HES6 antibody

3

(1 Review)

|

(2 Publications)

Rabbit Polyclonal HES6 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human HES6 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

BHLHB41, HES6, Transcription cofactor HES-6, C-HAIRY1, Class B basic helix-loop-helix protein 41, Hairy and enhancer of split 6, bHLHb41

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HES6 antibody (AB218037)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HES6 antibody (AB218037)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling HES6 using ab218037 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human HES6 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q96HZ4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

HES6 also known as Hairy and Enhancer of Split-6 is a protein involved in transcriptional regulation. It has a molecular mass of approximately 25 kilodaltons. Researchers find HES6 expression in multiple tissues including the brain muscle and pancreas. As a member of the bHLH (basic helix-loop-helix) transcription factor family HES6 negatively regulates transcription typically by antagonizing the activity of other transcription factors.
Biological function summary

HES6 influences cell differentiation and the timing of neurogenesis. It does not commonly act as part of a large complex but rather modulates activity by interacting directly with other transcription factors and regulatory proteins. Through these interactions HES6 helps control gene expression patterns important for the development of neural and muscular structures.

Pathways

HES6 participates in the Notch signaling pathway a critical mechanism for cell fate decisions. HES6 interacts with proteins such as HES1 and inhibition of some Notch pathway activities. This interaction influences cell differentiation processes particularly in the nervous system. Another pathway involving HES6 is the Wnt signaling pathway where it acts as a modulator in different cellular contexts though precise mechanical interactions within this pathway continue to be under investigation.

Researchers have associated HES6 with neurodegenerative diseases and muscle development disorders. In Alzheimer's disease for example dysregulation of the Notch pathway involving proteins such as HES1 and HES6 may contribute to pathogenesis. In muscular dystrophy alterations in the expression of HES6 could impact muscle repair and regeneration processes making it a target of interest for understanding and potentially treating such conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
See full target information HES6
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Polish journal of pathology : official journal of the Polish Society of Pathologists 75:274-286 PubMed39849871

2025

Enhancers of cancer stem cells and epithelial-mesenchymal transition: Lin28, MUC1, and lipocalin-2 as a new prognostic axis in classical invasive lobular carcinoma of the breast.

Applications

Unspecified application

Species

Unspecified reactive species

Mohamed Alabiad,Raja Aljafil,Amany Shalaby,Ahmed M Yehia,Mohammed Alorini,Basma Hamed Ibrahim

International journal of clinical and experimental 11:99-109 PubMed31938091

2018

polysaccharide extracts alleviate MPP-induced PC-12 cell injury through inhibition of Notch signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ruiting Liu,Xiaowan Li
View all publications
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