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AB21124

Anti-Hepatitis C Virus NS3 抗体

Anti-Hepatitis C Virus NS3 antibody

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(6 Publications)

Goat Polyclonal Hepatitis C Virus NS3 antibody. Suitable for ELISA, WB, ICC/IF and reacts with Hepatitis C virus samples. Cited in 6 publications.

別名を表示する

NS3, NS3P, Serine protease/NTPase/helicase, p70

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Hepatitis C virus

アプリケーション

ELISA, ICC/IF, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis C virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Ion exchange chromatography
精製に関する特記事項
Sodium sulfate precipitation & ion-exchange chromatography.
バッファー組成
Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Hepatitis C Virus NS3 also known as non-structural protein 3 is an important component of the Hepatitis C viral replication machinery. It functions as a serine protease and RNA helicase necessary for processing the HCV polyprotein and unwinding RNA respectively. The NS3 protein has a molecular mass of approximately 70 kDa and is expressed primarily in infected hepatocytes. It often comes up in research discussions during NS3 conferences and is a focus of many studies seeking to understand HCV replication mechanisms.
Biological function summary

NS3 plays a significant role in the life cycle of Hepatitis C Virus by facilitating viral replication and maturation. NS3 protease activity cleaves the non-structural protein precursors at multiple sites which is essential for the formation of the viral replication complex. As part of the HCV replication complex it associates with the NS4A cofactor that enhances its protease function. The protein is highly conserved and represents an attractive target for antiviral drug development due to its indispensable role in the viral life cycle.

Pathways

NS3 is integral to the viral replication and host immune evasion pathways. The protein interacts in the post-translational modification processing pathway that is critical for producing functional viral proteins. NS3 activity is closely related to other non-structural proteins such as NS5A and NS5B which are involved in RNA replication. These interactions form a network essential for the hepatitis C infection propagation influencing the virus's ability to hijack host cells' functions.

NS3 is directly associated with Hepatitis C a significant cause of chronic liver disease including cirrhosis and hepatocellular carcinoma. NS3's activity contributes to the persistence of the infection often evading host immune responses. The protein plays a role in the pathogenesis of Hepatitis C by modulating immune signaling pathways. NS3 also interacts with host proteins such as TLR3 involved in antiviral responses thereby impacting disease progression and leading to potential long-term liver damage. Researchers target NS3 in the development of direct-acting antivirals aiming to disrupt its enzymatic functions to curb Hepatitis C infection.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Hepatitis C Virus NS3
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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

bioRxiv : the preprint server for biology : PubMed34981051

2021

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

K Y Chen,T Krischuns,L Ortega Varga,E Harigua-Souiai,S Paisant,A Zettor,J Chiaravalli,D Courtney,A O'Brien,S C Baker,C Isel,F Agou,Y Jacob,A Blondel,N Naffakh

Proceedings of the National Academy of Sciences of 113:12484-12489 PubMed27791088

2016

Hepatitis C virus promotes virion secretion through cleavage of the Rab7 adaptor protein RILP.

Applications

Unspecified application

Species

Unspecified reactive species

Ann L Wozniak,Abby Long,Kellyann N Jones-Jamtgaard,Steven A Weinman

Oncogene 33:2826-35 PubMed23770846

2013

Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

H Quan,F Zhou,D Nie,Q Chen,X Cai,X Shan,Z Zhou,K Chen,A Huang,S Li,N Tang

Journal of virology 85:7989-8001 PubMed21680513

2011

Hepatitis C virus infection causes cell cycle arrest at the level of initiation of mitosis.

Applications

WB

Species

Unspecified reactive species

Rathi P Kannan,Lucinda L Hensley,Lauren E Evers,Stanley M Lemon,David R McGivern

Journal of viral hepatitis 17:784-93 PubMed20002299

2009

Role of Hepatitis C virus core protein in viral-induced mitochondrial dysfunction.

Applications

WB

Species

Hepatitis C virus

T Wang,R V Campbell,M K Yi,S M Lemon,S A Weinman

Journal of virology 83:7422-33 PubMed19458004

2009

Impaired replication of hepatitis C virus containing mutations in a conserved NS5B retinoblastoma protein-binding motif.

Applications

WB

Species

Unspecified reactive species

David R McGivern,Rodrigo A Villanueva,Sreedhar Chinnaswamy,C Cheng Kao,Stanley M Lemon
View all publications
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Abcam product promise

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