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AB2740

Anti-Hepatitis C Virus Core 1b 抗体 [C7-50]

Anti-Hepatitis C Virus Core 1b antibody [C7-50]

4

(3 Reviews)

|

(91 Publications)

Mouse Monoclonal POLG antibody. Suitable for IP, Flow Cyt, ELISA, WB and reacts with Hepatitis C virus samples. Cited in 91 publications.

別名を表示する

Capsid protein C, Core protein p19, Core protein p21, Hepatitis C Virus core protein

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

C7-50

アイソタイプ

IgG1

キャリアフリー

No

交差種

Hepatitis C virus

アプリケーション

IP, Flow Cyt, ELISA, WB

applications

エピトープ

This antibody recognizes an epitope between amino acid residues 21-40 of HCV core protein. This sequence is conserved among different HCV strains.

特異性

Detects hepatitis C virus (HCV) core protein from transfected human and primate cell lines.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis C virus": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "1/100", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p>This antibody detects a single ~21 kDa protein representing HCV core protein in various transfected cell lines.</p>" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Preservative: 0.05% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis C Virus Core 1b also recognized as HCV Core Protein or sometimes abbreviated as HCV Core is an important structural protein of the Hepatitis C Virus weighing approximately 21 kDa. This protein is mainly expressed in infected liver cells playing a central role in the virus's life cycle. It forms part of the viral nucleocapsid providing a protective shell for the viral genome. Through its structural role HCV Core Protein ensures the stability and integrity of the viral particles necessary for efficient infection and replication.
Biological function summary

The Hepatitis C Virus Core Protein influences various cellular processes. It interacts with host cell signaling pathways and cellular structures to facilitate viral replication. As part of a larger proteins complex the core protein contributes to the production of virus particles. Moreover it possesses regulatory roles that impact gene transcription and modulation of host cell immune responses further aiding viral propagation and persistence within the host.

Pathways

Studies show that HCV Core Protein is involved in disrupting normal cellular pathways such as the PI3K-Akt pathway which is significant for cell survival and anti-apoptosis mechanisms. It interacts with proteins like p53 and Bcl-2 which further link to the JAK-STAT pathway involved in immune modulation. These interactions illustrate how the core protein manipulates host cell environments to benefit viral survival and replication while potentially triggering pathogenic pathways within the host.

The Hepatitis C Virus Core Protein holds connections to liver diseases notably chronic hepatitis and hepatocellular carcinoma. These conditions arise from the persistent infection and the core protein's interference with apoptotic and immune pathways contributing to carcinogenesis. It relates closely with other viral proteins like NS5A which together exacerbate liver fibrosis and cancer development. The core protein's pathogenic role highlights its interest as a target for anti-HCV therapies potentially guiding therapeutic antibody development against hepatitis C like anti-HCV core antibodies or anti-hepatitis C antibodies.

製品プロトコール

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文献 (91)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 19:e1011552 PubMed37540723

2023

Hepatitis C virus non-structural proteins modulate cellular kinases for increased cytoplasmic abundance of host factor HuR and facilitate viral replication.

Applications

Unspecified application

Species

Unspecified reactive species

Harsha Raheja,Biju George,Sachin Kumar Tripathi,Sandhini Saha,Tushar Kanti Maiti,Saumitra Das

Frontiers in immunology 13:1007718 PubMed36532074

2022

Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Ni An,Qinghua Ge,Huihan Shao,Quanjie Li,Fei Guo,Chen Liang,Xiaoyu Li,Dongrong Yi,Long Yang,Shan Cen

Virology journal 19:118 PubMed35836293

2022

PPP2R5D promotes hepatitis C virus infection by binding to viral NS5B and enhancing viral RNA replication.

Applications

Unspecified application

Species

Unspecified reactive species

Muhammad Ikram Anwar,Ni Li,Qing Zhou,Mingxiao Chen,Chengguang Hu,Tao Wu,Haihang Chen,Yi-Ping Li,Yuanping Zhou

Virologica Sinica 37:408-417 PubMed35523417

2022

Enhanced host immune responses in presence of HCV facilitate HBV clearance in coinfection.

Applications

Unspecified application

Species

Unspecified reactive species

Shuhui Liu,Kaitao Zhao,Xi Su,Xiaoxiao Gao,Yongxuan Yao,Ranran Kong,Yun Wang,Chunchen Wu,Mengji Lu,Xinwen Chen,Rongjuan Pei

Nature communications 13:2079 PubMed35440123

2022

An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA.

Applications

Unspecified application

Species

Unspecified reactive species

Jianyuan Zhao,Jing Wang,Xu Pang,Zhenlong Liu,Quanjie Li,Dongrong Yi,Yongxin Zhang,Xiaomei Fang,Tao Zhang,Rui Zhou,Tao Zhang,Zhe Guo,Wancang Liu,Xiaoyu Li,Chen Liang,Tao Deng,Fei Guo,Liyan Yu,Shan Cen

The Journal of biological chemistry 298:101804 PubMed35257746

2022

Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A.

Applications

Unspecified application

Species

Unspecified reactive species

Daisuke Miyamoto,Kenji Takeuchi,Kazuyasu Chihara,Shigeharu Fujieda,Kiyonao Sada

Nature communications 12:6105 PubMed34671027

2021

Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure.

Applications

Unspecified application

Species

Unspecified reactive species

David A Smith,Carlota Fernandez-Antunez,Andrea Magri,Rory Bowden,Nimisha Chaturvedi,Jacques Fellay,John McLauchlan,Graham R Foster,William L Irving,Peter Simmonds,Vincent Pedergnana,Santseharay Ramirez,Jens Bukh,Eleanor Barnes,M Azim Ansari

Communications biology 4:564 PubMed33980978

2021

Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses.

Applications

Unspecified application

Species

Unspecified reactive species

Hung-Yu Sun,Tzu-Ying Chen,Yu-Ching Tan,Chun-Hsiang Wang,Kung-Chia Young

International journal of molecular medicine 47: PubMed33846769

2021

Mechanisms of microRNA‑142 in mitochondrial autophagy and hippocampal damage in a rat model of epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Du Xiao,Jingdan Lv,Zhigang Zheng,Yi Liu,Yonggen Zhang,Cuizhu Luo,Liu Qi,Bing Qin,Chao Liu

Journal of cellular and molecular medicine 25:3498-3510 PubMed33682288

2021

TGF-β isoforms inhibit hepatitis C virus propagation in transforming growth factor beta/SMAD protein signalling pathway dependent and independent manners.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Li Zou,Jian-Rui Li,Hu Li,Jia-Li Tan,Mei-Xi Wang,Nan-Nan Liu,Rong-Mei Gao,Hai-Yan Yan,Xue-Kai Wang,Biao Dong,Yu-Huan Li,Zong-Gen Peng
View all publications

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