AB8636

Anti-Hepatitis B Virus Surface Antigen 抗体 [S14]

Name: Anti-Hepatitis B Virus Surface Antigen 抗体 [S14] (ab8636) | Abcam
Brand: Abcam Limited
SKU: AB8636
Price: 60000 JPY
Availability: InStock

Anti-Hepatitis B Virus Surface Antigen antibody [S14]

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(4 Publications)

Mouse Monoclonal HBSAG antibody. Suitable for IP, ELISA, IHC-FoFr, ICC/IF, IHC-Fr and reacts with Hepatitis B virus samples. Cited in 4 publications.

別名を表示する

Large envelope protein, L glycoprotein, L-HBsAg, Large S protein, Large surface protein, Major surface antigen, LHB, S

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

S14

アイソタイプ

IgG2b

軽鎖のタイプ

kappa

キャリアフリー

交差種

Hepatitis B virus

アプリケーション

IP, IHC-FoFr, IHC-Fr, ICC/IF, ELISA

applications

エピトープ

unknown

特異性

This antibody reacts with HBV Small Surface Antigen

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis B virus": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "1/100", "IHCFoFr-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/100", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/100", "IHCFr-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Tissue culture supernatant

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis B Virus Surface Antigen commonly known as HBsAg is an important structural protein of the Hepatitis B Virus (HBV). This antigen is also referred to as Hep B surf Ab. Designed with a mass of approximately 24 kDa HBsAg is expressed extensively in the liver tissues of individuals infected with Hepatitis B. It represents the major component of the virus's envelope and plays a role in the formation of subviral particles. Several commercial antibodies such as Hepatitis antibodies and HBV antibodies target HBsAg for analytical and diagnostic purposes in laboratories.

Biological function summary

The Hepatitis B Virus Surface Antigen interacts with the host's immune system and assists in viral replication. HBsAg is not part of a larger protein complex. Rather it circulates as free particles known as 3e-7 and 3e-7 Hepatitis B antigens which are abundant in the blood serum during active infection. These particles act as decoys distracting the host's immune defense and facilitating the persistence of the infection. The production and clearance of HBsAg serve as important indicators of HBV infection status and disease progression.

Pathways

Hepatitis B Virus Surface Antigen plays an integral role in the HBV life cycle particularly within the viral entry and replication pathways. It shares a functional relationship with the HB5 protein which is important for viral particle assembly and release. The interactions between HBsAg and host proteins influence viral propagation and subsequently the overall pathway of HBV infection within hepatocytes. Understanding these interactions can aid in the development of therapeutic interventions to disrupt the viral lifecycle.

Hepatitis B Virus Surface Antigen is directly associated with chronic Hepatitis B infection and hepatocellular carcinoma. Chronic Hepatitis B characterized by the prolonged presence of HBsAg can advance to liver cirrhosis and cancer if untreated. The antigen's persistence is often monitored alongside liver enzymes and other markers such as Hepatitis B antibodies (Hep B antibodies) to assess disease progression and treatment efficacy. Effective management of HBsAg levels helps mitigate the risk and severity of these severe liver diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.. The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.

See full target information S

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:3523 PubMed36864072

2023

An innovative wireless electrochemical card sensor for field-deployable diagnostics of Hepatitis B surface antigen.

Applications

Unspecified application

Species

Unspecified reactive species

Prinjaporn Teengam,Pisit Tangkijvanich,Natthaya Chuaypen,Orawon Chailapakul

Cellular and molecular gastroenterology and hepatology 14:527-551 PubMed35643233

2022

HIRA Supports Hepatitis B Virus Minichromosome Establishment and Transcriptional Activity in Infected Hepatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Maëlle Locatelli,Jean-Pierre Quivy,Fleur Chapus,Maud Michelet,Judith Fresquet,Sarah Maadadi,Amel Neila Aberkane,Audrey Diederichs,Julie Lucifora,Michel Rivoire,Geneviève Almouzni,Barbara Testoni,Fabien Zoulim

Journal of immunology (Baltimore, Md. : 1950) 208:672-684 PubMed35022275

2022

Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-β1-Induced OCT4/Nanog Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenting Li,Xiaoqiong Duan,Chuanlong Zhu,Xiao Liu,Andre J Jeyarajan,Min Xu,Zeng Tu,Qiuju Sheng,Dong Chen,Chuanwu Zhu,Tuo Shao,Zhimeng Cheng,Shadi Salloum,Esperance A Schaefer,Annie J Kruger,Jacinta A Holmes,Raymond T Chung,Wenyu Lin

Cancer gene therapy 20:652-62 PubMed24310062

2013

DNA vaccine cocktail expressing genotype A and C HBV surface and consensus core antigens generates robust cytotoxic and antibody responses in mice and Rhesus macaques.

Applications

Unspecified application

Species

Unspecified reactive species

N Obeng-Adjei,N A Hutnick,J Yan,J S Chu,D J F Myles,M P Morrow,N Y Sardesai,D B Weiner

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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For licensing inquiries, please contact partnerships@abcam.com

Anti-Hepatitis B Virus Surface Antigen 抗体 [S14]

Anti-Hepatitis B Virus Surface Antigen antibody [S14]

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

エピトープ

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製度

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

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Secondary Antibodies

Primary Antibodies

Proteins & Peptides

Abcam product promise