AB8635

Anti-Hepatitis B Virus pre S2 Antigen 抗体 [S26]

Name: Anti-Hepatitis B Virus pre S2 Antigen 抗体 [S26] (ab8635) | Abcam
Brand: Abcam Limited
SKU: AB8635
Price: 78000 JPY
Availability: InStock
Rating: 4 (2 reviews)

Anti-Hepatitis B Virus pre S2 Antigen antibody [S26]

(2 Reviews)

(8 Publications)

Mouse Monoclonal Hepatitis B Virus pre S2 Antigen antibody. Suitable for IP, ELISA, WB, IHC-FoFr, IHC-P, IM, IHC-Fr and reacts with Hepatitis B virus, Transfected cell lysate - Hepatitis B virus samples. Cited in 8 publications.

別名を表示する

HBV pre S2 Antigen, HBV pre S2 protein, Hepatitis B Virus pre S2 protein, PreS2/S antigen

1 Images

AbReview23877****

Western blot - Anti-Hepatitis B Virus pre S2 Antigen antibody [S26] (AB8635)

All lanes:

Western blot - Anti-Hepatitis B Virus pre S2 Antigen antibody [S26] (ab8635) at 1/1000 dilution

Lane 1:

Whole cell lysate prepared from HEK cells at 50 µg

Lanes 2 - 3:

Whole cell lysate prepared from HEK cells transfected with pCI M at 50 µg

Secondary

All lanes:

Sheep anti-mouse HRP conjugated polyclonal at 1/1000 dilution

Observed band size: 33 kDa,36 kDa,39 kDa

true

Exposure time: 10min

Image courtesy of Alina Macovei by Abreview.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

S26

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

交差種

Hepatitis B virus

アプリケーション

IHC-FoFr, IHC-P, IM, ELISA, IP, IHC-Fr, WB

applications

エピトープ

aa positions 131-139 (adw nomenclature)

特異性

This antibody reacts with HBV Large and Middle Surface Antigen but not small forms (both glycosylated and non glycosylated species).

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IM" : {"fullname" : "Immunomicroscopy", "shortname":"IM"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis B virus": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFoFr-species-checked": "guaranteed", "IHCFoFr-species-dilution-info": "1/100", "IHCFoFr-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "", "IM-species-checked": "guaranteed", "IM-species-dilution-info": "", "IM-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/100", "IHCFr-species-notes": "" }, "Transfected cell lysate - Hepatitis B virus": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "ELISA-species-checked": "notRecommended", "ELISA-species-dilution-info": "", "ELISA-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "", "IHCFoFr-species-checked": "notRecommended", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IM-species-checked": "notRecommended", "IM-species-dilution-info": "", "IM-species-notes": "", "IHCFr-species-checked": "notRecommended", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }

style

left-column

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Hepatitis B Virus pre S2 antigen also known simply as pre S2 is a component of the Hepatitis B surface antigen (HBsAg). It plays a role in the viral life cycle and assists in the infection process of liver cells. The pre S2 antigen has a molecular mass of approximately 31 kDa. It is expressed on the surface of infected liver cells and virions where it facilitates the entry of the virus into the host cells.

Biological function summary

The pre S2 antigen is an integral part of the Hepatitis B viral structure participating in the initial attachment and penetration into hepatocytes. The pre S2 region of HBsAg is known for containing receptor-binding domains that interact with cellular surface molecules aiding in viral adherence and entry. These interactions are important for establishing infection making the pre S2 region a critical determinant in viral infectivity and host specificity.

Pathways

The pre S2 antigen plays a role in viral entry pathways involving liver-specific processes. During the Hepatitis B virus life cycle the pre S2 antigen interacts with the sodium taurocholate co-transporting polypeptide (NTCP) a transporter on hepatocytes which is essential for the virus's entry and subsequent replication within liver cells. This interaction highlights the importance of the antigen in the viral infection pathway and its involvement in the viral-host dynamics.

The pre S2 antigen is directly linked to Hepatitis B infection a major cause of liver disease including cirrhosis and hepatocellular carcinoma. Chronic infection with Hepatitis B and the presence of pre S2 can lead to serious liver damage over time. During the progression of these diseases elevated expression of pre S2 antigen is observed further influencing disease severity. The antigen’s role in facilitating viral entry and replication makes it a target for therapeutic interventions aimed at alleviating Hepatitis B-related liver disorders.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

See full target information Hepatitis B Virus pre S2 Antigen

style

left-column

文献 (8)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1013391 PubMed40763308

2025

HBV capsid assembly modulators differentially modulate the assembly of wild-type and drug-resistant core protein chimeric nucleocapsids and empty capsids.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Liu,Hemraj Rimal,Jun Lyu,Liangxian Shen,Qiong Zhao,Jinhong Chang,Ju-Tao Guo

Nature communications 14:8440 PubMed38114531

2023

NDP52 mediates an antiviral response to hepatitis B virus infection through Rab9-dependent lysosomal degradation pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shuzhi Cui,Tian Xia,Jianjin Zhao,Xiaoyu Ren,Tingtao Wu,Mireille Kameni,Xiaoju Guo,Li He,Jingao Guo,Aléria Duperray-Susini,Florence Levillayer,Jean-Marc Collard,Jin Zhong,Lifeng Pan,Frédéric Tangy,Pierre-Olivier Vidalain,Dongming Zhou,Yaming Jiu,Mathias Faure,Yu Wei

Journal of immunology (Baltimore, Md. : 1950) 208:672-684 PubMed35022275

2022

Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-β1-Induced OCT4/Nanog Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wenting Li,Xiaoqiong Duan,Chuanlong Zhu,Xiao Liu,Andre J Jeyarajan,Min Xu,Zeng Tu,Qiuju Sheng,Dong Chen,Chuanwu Zhu,Tuo Shao,Zhimeng Cheng,Shadi Salloum,Esperance A Schaefer,Annie J Kruger,Jacinta A Holmes,Raymond T Chung,Wenyu Lin

Human vaccines & immunotherapeutics 16:756-778 PubMed31687879

2019

A dendritic cell receptor-targeted chimeric immunotherapeutic protein (C-HBV) for the treatment of chronic hepatitis B.

Applications

Unspecified application

Species

Unspecified reactive species

Allan Ma,Bruce Motyka,Klaus Gutfreund,Yuenian Eric Shi,Rajan George

PloS one 11:e0159089 PubMed27434097

2016

Hepatitis B Virus Middle Protein Enhances IL-6 Production via p38 MAPK/NF-κB Pathways in an ER Stress-Dependent Manner.

Applications

Unspecified application

Species

Unspecified reactive species

Yang-Xia Li,Yan-Li Ren,Hai-Jing Fu,Ling Zou,Ying Yang,Zhi Chen

ACS nano 6:7634-43 PubMed22934963

2012

Hybrid nanocluster plasmonic resonator for immunological detection of hepatitis B virus.

Applications

Unspecified application

Species

Unspecified reactive species

Mohamed Shehata Draz,Binbin Amanda Fang,Lanjuan Li,Zhi Chen,Yingjie Wang,Yuhong Xu,Jun Yang,Kevin Killeen,Fanqing Frank Chen

Gastroenterology 136:168-176.e2 PubMed18996386

2008

In vitro characterization of viral fitness of therapy-resistant hepatitis B variants.

Applications

ICC/IF

Species

Unspecified reactive species

Stéphanie Villet,Gaëtan Billioud,Christian Pichoud,Julie Lucifora,Olivier Hantz,Camille Sureau,Paul Dény,Fabien Zoulim

Journal of virology 77:9511-21 PubMed12915565

2003

Pre-s1 antigen-dependent infection of Tupaia hepatocyte cultures with human hepatitis B virus.

Applications

Unspecified application

Species

Unspecified reactive species

Dieter Glebe,Mehriar Aliakbari,Peter Krass,Eva V Knoop,Klaus P Valerius,Wolfram H Gerlich

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Hepatitis B Virus pre S2 Antigen 抗体 [S26]

Anti-Hepatitis B Virus pre S2 Antigen antibody [S26]

Western blot - Anti-Hepatitis B Virus pre S2 Antigen antibody [S26] (AB8635)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

エピトープ

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (8)

組合せ製品

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Abcam product promise