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AB8637

Anti-Hepatitis B Virus Core Antigen 抗体 [C1]

Anti-Hepatitis B Virus Core Antigen antibody [C1]

4

(1 Review)

|

(33 Publications)

Anti-Hepatitis B Virus Core Antigen antibody [C1] (ab8637) is a mouse monoclonal antibody detecting Hepatitis B Virus Core Antigen in Western Blot, IP, ICC/IF, ELISA. Suitable for Hepatitis B virus.

- Over 20 publications
- Trusted since 2002

別名を表示する

Capsid Protein, Core and e antigen, Core antigen, Core protein, HBVgp4, HBc, HBcAg, Hepatitis B Virus core antigen, Hepatitis B core antigen, p21.5, precore/core protein

1 Images
Western blot - Anti-Hepatitis B Virus Core Antigen antibody [C1] (AB8637)
  • WB

Unknown

Western blot - Anti-Hepatitis B Virus Core Antigen antibody [C1] (AB8637)

Immunoblotting analysis of the recombinant HBcAg antigen using ab8637. E.coli lysates were separated using 12% SDS-PAAG electrophoresis, imunoblotted and developed with the Amersham ECL Detection Kit. Samples : 1. Negative control; 2. HBcAg (full length, 1-183)

All lanes:

Western blot - Anti-Hepatitis B Virus Core Antigen antibody [C1] (ab8637)

Predicted band size: 21 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

C1

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Hepatitis B virus

アプリケーション

WB, IP, ELISA, ICC/IF

applications

エピトープ

Around aa positions 70-80, major, or "c1" determinant

特異性

This antibody reacts with HBV Core Antigen (Major antigenic determinant, c1). Ab8637 should recognize both the precoreprotein and core protein. It will not recognize the precorprotein under native conditions, because this protein can not self assemble into particles.

Ab8637 was raised against serotype ayw but will work with all other genotypes.

Reactivity data

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製品の詳細

What is this antibody validated in?
Anti-Hepatitis B Virus Core Antigen antibody [C1] (ab8637) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in Hepatitis B virus samples.

Trusted by the scientific community
Anti-Hepatitis B Virus Core Antigen [C1] (ab8637) was first used in a scientific publication in 2002 and has been cited over 20 times in peer-reviewed journals.

出荷温度及び保存条件

製品の状態
Liquid
精製度
Tissue culture supernatant
バッファー組成
pH: 7.4 Constituents: 99% PBS, 0.1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis B Virus Core Antigen also known as HBV core antigen or Hep B core is an important component of the hepatitis B virus (HBV). This antigen often referred to simply as 'core' forms the nucleocapsid of the virus. The HBV core antigen consists of a protein structure with a mass of approximately 21 kilodaltons. It is primarily expressed within the hepatocytes the liver cells where it plays a pivotal role in viral replication and assembly. The HBV core antigen is also referred to in studies as HBV protein or B core.
Biological function summary

The hepatitis B core antigen is integral for the assembly of the viral capsid which protects the viral genome during infection. It functions as part of a larger complex with other viral proteins including the pre-core and envelope proteins to facilitate viral lifecycle processes. This antigen allows for the encapsidation of viral RNA and serves as a scaffold for reverse transcription of the viral genome ensuring replication fidelity and successful infection spread.

Pathways

The hepatitis B core antigen is essential in the viral replication pathway and the HBV lifecycle pathway. It interacts closely with HBV polymerase during the packaging of viral genome into the capsid. These interactions are important for the transformation of RNA into DNA a critical step in viral maturation. The antigen is related to the HBx protein through these pathways; the HBx protein modulates viral replication and can influence the pathogenesis of the virus.

The hepatitis B core antigen is strongly linked to chronic hepatitis B infection and liver diseases such as cirrhosis and hepatocellular carcinoma. The persistence of the core antigen in infected hepatocytes signifies ongoing viral replication which can lead to liver inflammation and damage. The interaction of the core antigen with immune system components such as anti-HBc antibodies assists in the diagnosis and monitoring of disease progression. It connects to the envelope proteins during the disease process which are important in immune system evasion and chronic infection establishment.

製品プロトコール

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文献 (33)

Recent publications for all applications. Explore the full list and refine your search

PLoS pathogens 21:e1012800 PubMed39746094

2025

Manganese is a potent inducer of lysosomal activity that inhibits de novo HBV infection.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Yu,Hao Chang,Wentao Xie,Yuan Zheng,Le Yang,Qiong Wu,Fan Bu,Yuanfei Zhu,Youhua Xie,Guoyu Pan,Ke Lan,Qiang Deng

Virology journal 21:310 PubMed39609857

2024

Obtaining HBV core protein VLPs carrying SARS-CoV-2 nucleocapsid conserved fragments as vaccine candidates.

Applications

Unspecified application

Species

Unspecified reactive species

Yadira Lobaina,Alexis Musacchio,Panchao Ai,Rong Chen,Edith Suzarte,Glay Chinea,Miaohong Zhang,Zhiqiang Zhou,Yaqin Lan,Ricardo Silva,Gerardo Guillén,Ke Yang,Wen Li,Yasser Perera,Lisset Hermida

JHEP reports : innovation in hepatology 6:101134 PubMed39386256

2024

CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1.

Applications

Unspecified application

Species

Unspecified reactive species

Valerio Taverniti,Laura Meiss-Heydmann,Cloé Gadenne,Hannah Vanrusselt,Dieudonné Buh Kum,Fabio Giannone,Patrick Pessaux,Catherine Schuster,Thomas F Baumert,Yannick Debing,Eloi R Verrier

Polish journal of microbiology 73:217-235 PubMed38905278

2024

Guanylate-Binding Protein 1 (GBP1) Enhances IFN-α Mediated Antiviral Activity against Hepatitis B Virus Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Yadi Li,Haiying Luo,Xiaoxia Hu,Jiaojiao Gong,Guili Tan,Huating Luo,Rui Wang,Hao Pang,Renjie Yu,Bo Qin

Journal of virology 98:e0150223 PubMed38315015

2024

Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level is dependent on core protein translation.

Applications

Unspecified application

Species

Unspecified reactive species

Jan Martin Berke,Ying Tan,Sarah Sauviller,Dai-Tze Wu,Ke Zhang,Nádia Conceição-Neto,Alfonso Blázquez Moreno,Desheng Kong,George Kukolj,Chris Li,Ren Zhu,Isabel Nájera,Frederik Pauwels

Cellular and molecular gastroenterology and hepatology 17:219-235 PubMed37879404

2023

Oncostatin M Induces IFITM1 Expression to Inhibit Hepatitis B Virus Replication Via JAK-STAT Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Yuchen Ye,Ya Fu,Caorui Lin,Ye Shen,Qingqing Yu,Xiaobao Yao,Qunfang Huang,Can Liu,Yongbin Zeng,Tianbin Chen,Songhang Wu,Zhen Xun,Qishui Ou

Journal of virology 97:e0109023 PubMed37787533

2023

Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection.

Applications

Unspecified application

Species

Unspecified reactive species

Yongqi Li,Yang Yang,Tianyang Li,Zhengmin Wang,Chunfeng Gao,Rilin Deng,Faxiang Ma,Xinyang Li,Licong Ma,Renyun Tian,Huiyi Li,Haizhen Zhu,Lei Zeng,Yanhang Gao,Guoyue Lv,Junqi Niu,Ian Nicholas Crispe,Zhengkun Tu

Journal of virology 97:e0072223 PubMed37754761

2023

Novel non-HAP class A HBV capsid assembly modulators have distinct and profiles.

Applications

Unspecified application

Species

Unspecified reactive species

Hannah Vanrusselt,Dieudonné Buh Kum,Valerio Taverniti,Cheng Liu,Abel Acosta Sanchez,Nikky Corthout,Sebastian Munck,Thomas F Baumert,Leonid Beigelman,Lawrence M Blatt,Julian A Symons,Jerome Deval,Pierre Raboisson,Eloi R Verrier,Andreas Jekle,Sandrine Vendeville,Yannick Debing

Microbiology spectrum :e0164123 PubMed37623314

2023

The dual functions of KDM7A in HBV replication and immune microenvironment.

Applications

Unspecified application

Species

Unspecified reactive species

Di Yang,Renyun Tian,Rilin Deng,Binbin Xue,Shun Liu,Luoling Wang,Huiyi Li,Qian Liu,Mengyu Wan,Songqing Tang,Xiaohong Wang,Haizhen Zhu

Viruses 15: PubMed37243280

2023

Canocapavir Is a Novel Capsid Assembly Modulator Inducing a Conformational Change of the Linker Region of HBV Core Protein.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Zheng,Le Yang,Lin Yu,Yuanfei Zhu,Yang Wu,Zhijun Zhang,Tian Xia,Qiang Deng
View all publications

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