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AB20269

Anti-Hepatitis A Virus 抗体

Anti-Hepatitis A Virus antibody

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(1 Publication)

Goat Polyclonal Hepatitis A Virus antibody. Suitable for ELISA and reacts with Hepatitis A virus samples. Cited in 1 publication. Immunogen corresponding to Virus preparation containing Hepatitis A Virus protein.

別名を表示する

HAV

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Hepatitis A virus

アプリケーション

ELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

All viral antigens. Negative cross reactivity against MRC5 cells.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Hepatitis A virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/1000", "ELISA-species-notes": "<p>This product may be used in place of neat antiserum in almost any appropriate antibody-based technique.</p>" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
Sodium sulfate precipitation and ion exchange chromatography.
バッファー組成
Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Hepatitis A Virus (HAV) is a small non-enveloped virus belonging to the Picornaviridae family. It possesses a single-stranded RNA genome that measures about 7.5 kilobases in length. The capsid of HAV with a mass around 27 kDa consists of proteins VP1 VP2 and VP3 which form a protective shell that facilitates the virus's stability and transmission. This virus is primarily found in the liver where it causes infection although it can also circulate in the bloodstream and be excreted in the feces.
Biological function summary

HAV plays a significant role in human health by causing liver inflammation. It does not form complexes with other proteins but its replication predominantly occurs in hepatocytes. Although HAV is not directly involved in forming complexes it effectively interacts with host cell machinery to produce viral proteins and new viral particles. These interactions ensure the virus thrives in a new environment by altering the cell's normal functions to favor its replication.

Pathways

HAV significantly influences immune response and inflammation pathways. The virus triggers these pathways to counter the body's antiviral defenses leading to liver inflammation and damage. During the infection HAV interacts with host proteins such as those regulating the interferon response potentially altering their normal biological roles. These interactions can modulate the signaling further complicating the immune response and enhancing viral replication.

HAV is most associated with acute hepatitis a liver disease characterized by jaundice fatigue and fever. The immune response exacerbates liver damage as the body attempts to clear the virus. Unlike some other hepatotropic viruses HAV does not cause chronic liver disease. The interaction of HAV with proteins involved in the inflammatory response such as cytokines exacerbates symptoms and impacts disease progression.

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 11:e0162384 PubMed27598782

2016

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjia Fan,Shahab Zareyan,Wenchen Zhao,Yoko Shimizu,Tom A Pfeifer,Jun-Hyung Tak,Murray B Isman,Bernard Van den Hoven,Mark E Duggan,Michael W Wood,Cheryl L Wellington,Iva Kulic
View all publications

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