AB48135

Anti-Hemopexin 抗体

Name: Anti-Hemopexin 抗体 (ab48135) | Abcam
Brand: Abcam Limited
SKU: AB48135
Price: 76000 JPY
Availability: InStock

Anti-Hemopexin antibody

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(1 Publication)

Rabbit Polyclonal Hemopexin antibody. Suitable for sELISA and reacts with Purified native protein - Human samples. Cited in 1 publication. Immunogen corresponding to Native Full Length Protein corresponding to Human Hemopexin.

別名を表示する

Hemopexin, Beta-1B-glycoprotein, HPX

1 Images

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)

sELISA

Unknown

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)

Standard Curve for Hemopexin (Analyte : Hemopexin protein (ab98988)); dilution range 1pg/ml to 1μg/ml using Capture Antibody Mouse monoclonal [32] to Hemopexin (ab27711) at 5μg/ml and Detector Antibody Rabbit polyclonal to Hemopexin (ab48135) at 0.5μg/ml.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

sELISA

applications

免疫原

Native Full Length Protein corresponding to Human Hemopexin.

P02790

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "predicted", "sELISA-species-dilution-info": "", "sELISA-species-notes": "" }, "Purified native protein - Human": { "sELISA-species-checked": "testedAndGuaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p>For sandwich ELISA, use this antibody as Detection at 0.5 µg/ml with Mouse monoclonal [32] to Hemopexin (<a href='/products/primary-antibodies/hemopexin-antibody-32-ab27711'>ab27711</a>) as Capture.</p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

バッファー組成

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Hemopexin also known as HPX is a glycoprotein that transports heme in the blood. It has a molecular weight of approximately 57 kDa and is primarily expressed in the liver. Hemopexin binds to free heme with high affinity which prevents oxidative damage and conserves iron. It transports the heme to hepatocytes for breakdown and recycling protecting cells from iron-mediated toxicity and oxidative stress.

Biological function summary

The hemopexin function relates to protecting tissues from the harmful effects of free heme. Hemopexin does not work as part of a complex in this process but mainly acts independently. Its high binding affinity plays an important role in maintaining heme homeostasis in the plasma and tissues. By controlling heme levels hemopexin supports overall cellular health and function.

Pathways

The hemopexin molecular weight allows it to fit effectively within the heme metabolism and iron recycling pathways. This protein plays a significant role by delivering heme to the liver and facilitating its degradation by heme oxygenase. Hemopexin interacts closely with heme oxygenase and albumin two proteins important for the management of heme and iron levels in the body.

Several hemopexin functions contribute to the understanding of conditions such as hemolytic anemia and acute liver injury. In hemolytic anemia hemopexin helps mitigate the effects of increased heme levels due to excessive red blood cell breakdown. In the context of liver injury the protein assists in the detoxification process and supports hepatic function. Hemopexin-related proteins such as heme oxygenase link these diseases to hemopexin by their roles in managing oxidative stress and heme catabolism.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

See full target information Hemopexin

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 47:6130-6144 PubMed31037292

2019

Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Tongxing Song,Yang Yang,Hongkui Wei,Xiaowei Xie,Jinxin Lu,Qianhui Zeng,Jie Peng,Yuanfei Zhou,Siwen Jiang,Jian Peng

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Hemopexin 抗体

Anti-Hemopexin antibody

Sandwich ELISA - Anti-Hemopexin antibody (AB48135)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

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Abcam product promise