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AB239495

Anti-Hemojuvelin 抗体 [C6]

Anti-Hemojuvelin antibody [C6]

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(1 Publication)

Mouse Monoclonal Hemojuvelin antibody. Suitable for WB, IHC-P and reacts with Pig, Human, Rat, Recombinant fragment - Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HJV aa 200 to C-terminus.

別名を表示する

HFE2, RGMC, HJV, Hemojuvelin, Hemochromatosis type 2 protein, Hemojuvelin BMP coreceptor, RGM domain family member C

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)

Paraffin-embedded human glioma tissue stained for Hemojuvelin using ab239495 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)

Paraffin-embedded human liver tissue stained for Hemojuvelin using ab239495 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)

Paraffin-embedded human kidney tissue stained for Hemojuvelin using ab239495 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C6] (AB239495)

Paraffin-embedded human prostate cancer tissue stained for Hemojuvelin using ab239495 at 30 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-Hemojuvelin antibody [C6] (AB239495)
  • WB

Supplier Data

Western blot - Anti-Hemojuvelin antibody [C6] (AB239495)

All lanes:

Western blot - Anti-Hemojuvelin antibody [C6] (ab239495) at 2 µg/mL

Lane 1:

Pig liver lysate

Lane 2:

Rat liver lysate

Secondary

All lanes:

HRP-Linked Rabbit Anti-Mouse IgG at 1/5000 dilution

Predicted band size: 45 kDa

false

Western blot - Anti-Hemojuvelin antibody [C6] (AB239495)
  • WB

Supplier Data

Western blot - Anti-Hemojuvelin antibody [C6] (AB239495)

All lanes:

Western blot - Anti-Hemojuvelin antibody [C6] (ab239495) at 2 µg/mL

All lanes:

Recombinant human Hemojuvelin protein

Secondary

All lanes:

HRP-linked Rabbit anti-Mouse IgG at 1/5000 dilution

Predicted band size: 45 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

C6

アイソタイプ

IgG2b

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Rat, Human, Pig

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human HJV aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6ZVN8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-30 µg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
精製に関する特記事項
Purified from TCS.
バッファー組成
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Hemojuvelin also known as HJV or RGMc is a glycosylphosphatidylinositol-anchored protein that plays a significant role in iron homeostasis. It has a molecular mass of about 42 kDa. Expression of hemojuvelin is mainly observed in the liver heart and skeletal muscles. This protein is essential for maintaining systemic iron levels and regulates how much iron is absorbed and stored in the body.
Biological function summary

Hemojuvelin interacts with other proteins to modulate iron metabolism. It acts as a coreceptor for bone morphogenetic proteins (BMPs) enhancing BMP signaling which is critical in regulating the peptide hormone hepcidin. Hemojuvelin itself is not part of a larger complex but it works closely with BMPs to control hepcidin expression. Hepcidin is the key hormone that dictates iron absorption and its release from macrophages maintaining iron balance.

Pathways

Hemojuvelin functions primarily within the BMP signaling and hepcidin regulatory pathways. The interaction with BMP6 is particularly critical. The BMP6-hemojuvelin complex boosts the SMAD signaling cascade resulting in increased hepcidin expression. This cascade impacts iron levels in the body by limiting intestinal iron absorption and controlling iron recycling by macrophages.

Hemojuvelin mutations can lead to juvenile hemochromatosis a condition characterized by excessive iron buildup in the body. This protein's dysfunction can severely affect iron homeostasis leading to detrimental health outcomes. Moreover its connection to the regulation of hepcidin links hemojuvelin to conditions like anemia of chronic disease where hepcidin expression is aberrantly increased or decreased. Understanding the interaction of hemojuvelin and hepcidin provides insights into the mechanisms behind these iron-related disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Acts as a bone morphogenetic protein (BMP) coreceptor (PubMed : 18976966). Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis (PubMed : 18976966).
See full target information HJV
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Digestive diseases and sciences : PubMed32440745

2020

Development of Pancreatic Acinar Cell Metaplasia During Gastric Repair in a Rat Duodenal Contents Reflux Model.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuhiro Wada,Ken-Ichi Mukaisho,Shunpei Kanai,Takahisa Nakayama,Masahide Fukuda,Kazuhiro Mizukami,Tadayoshi Okimoto,Masaaki Kodama,Hiroyuki Sugihara,Kazunari Murakami,Ryoji Kushima
View all publications
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代替製品

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Western blot - Anti-Hemojuvelin antibody (AB187529)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [C1] (AB239591)

  • 0
  • 0
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Hemojuvelin antibody [A7] (AB239492)

  • 0
  • 0

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