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AB20459

Anti-Helicobacter pylori 抗体

Anti-Helicobacter pylori antibody

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(10 Publications)

Rabbit Polyclonal Helicobacter pylori antibody. Suitable for ELISA, IHC-P, ICC/IF and reacts with Helicobacter pylori samples. Cited in 10 publications. Immunogen corresponding to Cell preparation containing Helicobacter pylori protein.

別名を表示する

H. pylori

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Helicobacter pylori

アプリケーション

ICC/IF, IHC-P, ELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

Whole cell lysate. Has not been absorbed and may react with related microorganisms.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Helicobacter pylori": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/5000", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "1/1000", "ICCIF-species-notes": "<p></p>" } } }
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下記製品もご検討ください

AB172611

Anti-Helicobacter pylori antibody [EPR10353]

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0 Reviews
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
精製に関する特記事項
>95% pure
バッファー組成
Preservative: 0.1% Sodium azide Constituents: 0.0268% PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Helicobacter pylori often called H. pylori is a gram-negative spiral-shaped bacterium with a mass of about 3.39 megadaltons. This organism colonizes the human gastric epithelium where it survives in the acidic environment of the stomach. The bacterium expresses urease which breaks down urea to ammonia and carbon dioxide helping neutralize gastric acid. It attaches to the gastric mucosa using flagella for motility and adheres to host cells via adhesins. Researchers utilize specific staining methods such as the Helicobacter pylori stain and tools like anti-Helicobacter antibodies to detect and study this pathogen.
Biological function summary

Helicobacter pylori plays a significant role in gastric health by disrupting mucosal integrity. It engages in the secretion of virulence factors like CagA and VacA leading to changes in cellular signaling and inflammation. H. pylori does not operate as part of a large complex but its interactions with the gastric mucosa have substantial effects. Detection and diagnosis often employ tools like H. pylori IHC and H. pylori antibody kits which target the bacterium's proteins to confirm infection presence.

Pathways

H. pylori infection activates signaling routes including the NF-κB pathway and the MAPK pathway in gastric epithelial cells. These pathways contribute to inflammatory responses and immune cell activation leading to mucosal damage. Within these pathways proteins like tumor necrosis factor-alpha (TNF-α) and interleukin-8 (IL-8) play roles in mediating inflammation initiated by the bacterial colonization of the gastric lining.

Chronic H. pylori infection has strong associations with gastric ulcers and gastric cancer. The bacterium promotes persistent inflammation and cellular damage that can progress to malignancy. H. pylori-related disorders are linked with proteins such as CagA a known oncogenic factor that interferes with host cell signaling and promotes carcinogenesis. Detection and specific targeting by Helicobacter pylori antibodies play important roles in managing and studying these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Helicobacter pylori
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文献 (10)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in microbiology 13:962354 PubMed36147839

2022

Revealing the novel effect of Jinghua Weikang capsule against the antibiotic resistance of .

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofen Jia,Qiuyue Huang,Miaomiao Lin,Yingming Chu,Zongming Shi,Xuezhi Zhang,Hui Ye

Journal of biomedical science 28:72 PubMed34706729

2021

Enhanced enzymatic production of cholesteryl 6'-acylglucoside impairs lysosomal degradation for the intracellular survival of Helicobacter pylori.

Applications

Unspecified application

Species

Unspecified reactive species

Sasikala Muthusamy,Hau-Ming Jan,Ming-Yen Hsieh,Soumik Mondal,Wen-Chun Liu,Yi-An Ko,Wei-Yuan Yang,Kwok-Kong Tony Mong,Guang-Chao Chen,Chun-Hung Lin

Frontiers in microbiology 12:674560 PubMed34149664

2021

Unraveling the Novel Effect of Patchouli Alcohol Against the Antibiotic Resistance of .

Applications

Unspecified application

Species

Unspecified reactive species

Yuanzun Zhong,Liyao Tang,Qiuhua Deng,Li Jing,Jiao Zhang,Yao Zhang,Feng Yu,Yijun Ou,Shaoju Guo,Bin Huang,Hongying Cao,Ping Huang,Yifei Xu

Frontiers in cellular and infection microbiology 10:566730 PubMed33194806

2020

Vitamin D3 Inhibits Infection by Activating the VitD3/VDR-CAMP Pathway in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Anni Zhou,Lei Li,Guiping Zhao,Li Min,Si Liu,Shengtao Zhu,Qingdong Guo,Chunjie Liu,Shutian Zhang,Peng Li

Molecular cell 80:210-226.e7 PubMed33002424

2020

A Repeat-Associated Small RNA Controls the Major Virulence Factors of Helicobacter pylori.

Applications

Unspecified application

Species

Unspecified reactive species

Sara K Eisenbart,Mona Alzheimer,Sandy R Pernitzsch,Sascha Dietrich,Stephanie Stahl,Cynthia M Sharma

Communications biology 3:120 PubMed32170208

2020

Cholesteryl α-D-glucoside 6-acyltransferase enhances the adhesion of Helicobacter pylori to gastric epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Hau-Ming Jan,Yi-Chi Chen,Tsai-Chen Yang,Lih-Lih Ong,Chia-Chen Chang,Sasikala Muthusamy,Andualem Bahiru Abera,Ming-Shiang Wu,Jacquelyn Gervay-Hague,Kwok-Kong Tony Mong,Chun-Hung Lin

Applied and environmental microbiology 84: PubMed29752266

2018

Helicobacter pylori Biofilm Formation Is Differentially Affected by Common Culture Conditions, and Proteins Play a Central Role in the Biofilm Matrix.

Applications

Unspecified application

Species

Unspecified reactive species

Ian H Windham,Stephanie L Servetas,Jeannette M Whitmire,Daniel Pletzer,Robert E W Hancock,D Scott Merrell

Proceedings of the National Academy of Sciences of 114:11027-11033 PubMed28973871

2017

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel C Propheter,Andrew L Chara,Tamia A Harris,Kelly A Ruhn,Lora V Hooper

PloS one 8:e65837 PubMed23734261

2013

Rapid identification of novel immunodominant proteins and characterization of a specific linear epitope of Campylobacter jejuni.

Applications

Unspecified application

Species

Unspecified reactive species

Sebastian Hoppe,Frank F Bier,Markus von Nickisch-Rosenegk,Markus V Nickisch-Rosenegk

Glycobiology 22:1193-206 PubMed22522599

2012

Almost all human gastric mucin O-glycans harbor blood group A, B or H antigens and are potential binding sites for Helicobacter pylori.

Applications

Unspecified application

Species

Unspecified reactive species

Yannick Rossez,Emmanuel Maes,Tony Lefebvre Darroman,Pierre Gosset,Chantal Ecobichon,Marie Joncquel Chevalier Curt,Ivo G Boneca,Jean-Claude Michalski,Catherine Robbe-Masselot
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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