Anti-hCG 抗体 (ab54410)
Key features and details
- Rabbit polyclonal to hCG
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-hCG antibody
hCG 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to hCG -
由来種
Rabbit -
特異性
This antibody recognises both alpha and beta subunits of hCG. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Purified Chorionic Gonadotropin from human placental glucoprotein urine.
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ポジティブ･コントロール
- Purified human CG and rat liver tissue lysate.
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特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 5778 Chorionic Gonadotropin (CG) Antibody. 5778-100 is the same size as the 100 µg size of ab54410.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 0.5% BSA, 30% Glycerol (glycerin, glycerine), PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab54410の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 0.5 - 4 µg/ml.
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| 特記事項 |
|---|
|
WB
Use a concentration of 0.5 - 4 µg/ml. |
ターゲット情報
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関連性
Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma. -
細胞内局在
Secreted -
参照データベース
- Entrez Gene: 1081 Human
- Entrez Gene: 1082 Human
- Omim: 118850 Human
- Omim: 118860 Human
- SwissProt: P01215 Human
- SwissProt: P01233 Human
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別名
- anterior pituitary glycoprotein hormones common subunit alpha antibody
- CG alpha antibody
- CG-ALPHA antibody
see all
画像
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Western blot - Anti-hCG antibody (ab54410)All lanes : Anti-hCG antibody (ab54410) (0.5-4 ug/m)
Lane 1 : Recombinant Human Chorionic Gonadotropin at 0.01 µg
Lane 2 : Recombinant Human Chorionic Gonadotropin at 0.05 µg
Lane 3 : Recombinant Human Chorionic Gonadotropin at 0.25 µg
Lane 4 : Recombinant Human Chorionic Gonadotropin at 1 µgThis information is only intended as a guide. The optimal dilutions must be determined by the user.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab54410 は 9 報の論文で使用されています。
- Mahr RM et al. Mitochondrial citrate metabolism and efflux regulate BeWo differentiation. Sci Rep 13:7387 (2023). PubMed: 37149697
- Zhu H et al. NPFF increases fusogenic proteins syncytin 1 and syncytin 2 via GCM1 in first trimester primary human cytotrophoblast cells. FASEB J N/A:N/A (2020). PubMed: 32501590
- Hong G et al. New photothermal immunoassay of human chorionic gonadotropin using Prussian blue nanoparticle-based photothermal conversion. Anal Bioanal Chem 411:6837-6845 (2019). PubMed: 31471682
- Lu X et al. Twist1 is involved in trophoblast syncytialization by regulating GCM1. Placenta 39:45-54 (2016). PubMed: 26992674
- Li Y et al. Involvement of nephrin in human placental trophoblast syncytialization. Reproduction 149:339-46 (2015). PubMed: 25614620
- Zhou Z et al. The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization. Placenta 35:907-18 (2014). PubMed: 25175744
- Wang R et al. Live cell imaging of in vitro human trophoblast syncytialization. Biol Reprod 90:117 (2014). PubMed: 24740598
- Zhou Z et al. The proprotein convertase furin is required for trophoblast syncytialization. Cell Death Dis 4:e593 (2013). WB ; Human . PubMed: 23598405
- Dukic-Stefanovic S et al. Chorionic gonadotropin and its receptor are both expressed in human retina, possible implications in normal and pathological conditions. PLoS One 7:e52567 (2012). WB ; Human . PubMed: 23285091