Anti-Haptoglobin 抗体 [HG-36] (ab13429)
Key features and details
- Mouse monoclonal [HG-36] to Haptoglobin
- Suitable for: ELISA, Dot blot, ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Haptoglobin antibody [HG-36]
Haptoglobin 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [HG-36] to Haptoglobin -
由来種
Mouse -
アプリケーション
適用あり: ELISA, Dot blot, ICC/IF, WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Full length native protein (Purified haptoglobin types 1-1, 2-1, and 2-2 from pooled human plasma).
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特記事項
This product was changed from ascites to tissue culture supernatant on 17 May 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.098% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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精製度
Proprietary Purification -
特記事項(精製)
Purified from hybridoma cell culture -
ポリ/モノ
モノクローナル -
クローン名
HG-36 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab13429の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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Dot blot |
Use at an assay dependent concentration.
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ICC/IF | (2) |
Use at an assay dependent concentration.
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WB | (2) |
Use at an assay dependent concentration. Predicted molecular weight: 45 kDa.
|
IHC-P | (4) |
Use at an assay dependent concentration.
See Abreview. |
特記事項 |
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ELISA
Use at an assay dependent concentration. |
Dot blot
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 45 kDa. |
IHC-P
Use at an assay dependent concentration. See Abreview. |
ターゲット情報
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機能
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. -
組織特異性
Expressed by the liver and secreted in plasma. -
関連疾患
Anhaptoglobinemia -
配列類似性
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 2 Sushi (CCP/SCR) domains. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 3240 Human
- Omim: 140100 Human
- SwissProt: P00738 Human
- Unigene: 513711 Human
- Unigene: 702099 Human
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別名
- Binding peptide antibody
- BP antibody
- Haptoglobin alpha chain antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (19)
ab13429 は 19 報の論文で使用されています。
- Aso M et al. First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency. Heliyon 8:e11271 (2022). PubMed: 36387451
- Gunzer S et al. Hypertransaminasemia and liver fibrosis associated with haptoglobin retention and anhaptoglobinemia in a paediatric patient. Liver Int 41:2427-2432 (2021). PubMed: 34358398
- Calvo E et al. Why Does COVID-19 Affect Patients with Spinal Cord Injury Milder? A Case-Control Study: Results from Two Observational Cohorts. J Pers Med 10:N/A (2020). PubMed: 33096722
- Cao J et al. Identification of an activation-related protein in B cells in the ABO incompatible condition. Exp Ther Med 19:741-747 (2020). PubMed: 31897108
- Arya R et al. Serum Small Extracellular Vesicles Proteome of Tuberculosis Patients Demonstrated Deregulated Immune Response. Proteomics Clin Appl 14:e1900062 (2020). PubMed: 31532894