Anti-Guanylate Cyclase 抗体

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Guanylate cyclase serves critical signaling functions affecting numerous physiological processes. It is often part of a protein complex and leads to the generation of cGMP a second messenger that influences vascular tone platelet aggregation and neurotransmission. When guanylate cyclase is activated it sets off a cascade of cellular events which modulate these processes by influencing ion channels phosphodiesterases and cGMP-dependent protein kinases. These roles highlight its involvement in maintaining homeostatic functions and facilitating rapid cellular responses to a variety of stimuli.

Pathways

Guanylate cyclase influences significant signaling pathways such as the NO-cGMP pathway and the atrial natriuretic peptide (ANP) pathway. In the NO-cGMP pathway guanylate cyclase interacts prominently with nitric oxide synthases which produce NO to activate sGC leading to cGMP synthesis and smooth muscle relaxation. Similarly in the ANP pathway guanylate cyclase-A (one of the membrane-bound forms) responds to natriuretic peptides by increasing cGMP levels affecting blood volume and pressure. This connectivity further emphasizes its pivotal role in cardiovascular regulation.