Anti-Growth Hormone 抗体 [GH-2] (ab9822)
Key features and details
- Mouse monoclonal [GH-2] to Growth Hormone
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Growth Hormone antibody [GH-2]
Growth Hormone 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [GH-2] to Growth Hormone -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to Human Growth Hormone.
Database link: P01241 -
特記事項
This product was changed from ascites to tissue culture supernatant on 28/11/2017. Lot numbers higher than GR172544-1 and GR172544-3 will be from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.2
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
IgG fraction -
ポリ/モノ
モノクローナル -
クローン名
GH-2 -
ミエローマ
unknown -
アイソタイプ
IgG1 -
軽鎖の種類
unknown -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab9822の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/1000 - 1/5000.
|
特記事項 |
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WB
1/1000 - 1/5000. |
ターゲット情報
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機能
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. -
関連疾患
Defects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH.
Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.
Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI.
Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy. -
配列類似性
Belongs to the somatotropin/prolactin family. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 2688 Human
- Omim: 139250 Human
- SwissProt: P01241 Human
- Unigene: 655229 Human
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別名
- gH antibody
- GH-N antibody
- GH1 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab9822 は 3 報の論文で使用されています。
- Fradkin AH et al. Immunogenicity of aggregates of recombinant human growth hormone in mouse models. J Pharm Sci 98:3247-64 (2009). ELISA ; Mouse . PubMed: 19569057
- Kunert R et al. CHO-recombinant human growth hormone as a protease sensitive reporter protein. Appl Microbiol Biotechnol 84:693-9 (2009). PubMed: 19396439
- Markaki M et al. Stable expression of human growth hormone over 50 generations in transgenic insect larvae. Transgenic Res 16:99-107 (2007). PubMed: 17103025