AB9821

Anti-Growth Hormone 抗体 [GH-1]

Name: Anti-Growth Hormone 抗体 [GH-1] (ab9821) | Abcam
Brand: Abcam Limited
SKU: AB9821
Price: 75000 JPY
Availability: InStock

Anti-Growth Hormone antibody [GH-1]

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(6 Publications)

Mouse Monoclonal Growth Hormone antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GH1.

別名を表示する

Somatotropin, Growth hormone, Growth hormone 1, Pituitary growth hormone, GH, GH-N, GH1

2 Images

Unknown

Western blot - Anti-Growth Hormone antibody [GH-1] (AB9821)

Western blot of human growth hormone using ab9821 at a concentration of 1 μg/ml.

All lanes:

Western blot - Anti-Growth Hormone antibody [GH-1] (ab9821)

Predicted band size: 25 kDa

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Unknown

Western blot - Anti-Growth Hormone antibody [GH-1] (AB9821)

All lanes:

Western blot - Anti-Growth Hormone antibody [GH-1] (ab9821) at 1/500 dilution

Lane 1:

Western blot - Recombinant human Growth Hormone protein (Active) (<a href='/products/proteins-peptides/recombinant-human-growth-hormone-protein-active-ab51232'>ab51232</a>) at 0.1 µg

Lane 2:

Western blot - Recombinant human Growth Hormone protein (Active) (<a href='/products/proteins-peptides/recombinant-human-growth-hormone-protein-active-ab51232'>ab51232</a>) at 0.01 µg

Secondary

All lanes:

Western blot - Goat Anti-Mouse IgG H&L (HRP) preadsorbed (<a href='/products/secondary-antibodies/goat-mouse-igg-h-l-hrp-preadsorbed-ab97040'>ab97040</a>) at 1/5000 dilution

Predicted band size: 25 kDa

true

Exposure time: 2min

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

GH-1

アイソタイプ

IgG1

軽鎖のタイプ

unknown

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

Recombinant Full Length Protein corresponding to Human GH1.

P01241

エピトープ

Ab9821 recognizes a different epitope than GH-2 (ab9822).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }

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製品の詳細

This product was changed from ascites to tissue culture supernatant on 28/11/2017. Please note that the dilutions may need to be adjusted accordingly.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Growth Hormone (GH) also known as somatotropin is a polypeptide hormone with a mass of approximately 22 kDa. The pituitary gland synthesizes and secretes GH. Once synthesized GH circulates in the bloodstream and affects various tissues throughout the body. GH's expression is tightly regulated because of its significant roles in growth processes. Researchers might use anti-growth hormone antibodies and various hGH testing kits including ELISA to study its levels and functions.

Biological function summary

GH triggers growth and cell reproduction by exerting effects on multiple tissues. It binds to the growth hormone receptor which initiates a cascade of reactions that ultimately stimulates growth in muscle bone and cartilage. GH also contributes to protein synthesis and helps regulate metabolism. GH acts mostly independently but can interact with cytokines and other hormones.

Pathways

GH plays important roles in the regulation of the JAK-STAT signaling pathway and the IGF-1 signaling pathway. The JAK-STAT pathway is important for transmitting the signal of GH binding to its receptor into cellular responses. GH stimulates IGF-1 production in the liver and IGF-1 then acts in an endocrine manner to mediate much of GH’s growth-promoting activity. These interactions highlight the interconnectedness of GH with other hormones in growth signaling networks.

Several health conditions can arise from abnormal levels of GH. Dwarfism occurs due to GH deficiency while acromegaly results from GH excess. Clinical analysis might use hGH kits to measure hormone levels and aid in diagnosis. GH's role in such conditions links it to other hormones like insulin and glucagon that help regulate glucose levels further affecting metabolic processes. Recombinant forms of GH are used in therapy for these disorders providing avenues for treatment and management.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

See full target information GH1

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Analytical and bioanalytical chemistry 414:6187-6200 PubMed35838770

2022

Selective quantification of the 22-kDa isoform of human growth hormone 1 in serum and plasma by immunocapture and LC-MS/MS.

Applications

Unspecified application

Species

Unspecified reactive species

Bas Sleumer,Martijn van Faassen,Michel J Vos,Rainer Bischoff,Ido P Kema,Nico C van de Merbel

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 1144:122079 PubMed32247186

2020

Intact protein quantification in biological samples by liquid chromatography - high-resolution mass spectrometry: somatropin in rat plasma.

Applications

Unspecified application

Species

Unspecified reactive species

Peter Bults,Anders Sonesson,Magnus Knutsson,Rainer Bischoff,Nico C van de Merbel

International journal of molecular medicine 42:3037-3046 PubMed30272367

2018

Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Liu,Yanling Liu,Guolin Li,Zhengrong Chen,Guixiong Gu

Nature communications 7:10339 PubMed26842342

2016

A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Han Sun,Liqun Luo,Bachchu Lal,Xinrong Ma,Lieping Chen,Christine L Hann,Amy M Fulton,Daniel J Leahy,John Laterra,Min Li

Biosensors & bioelectronics 25:395-9 PubMed19692224

2009

Immobilization of specific monoclonal antibody on Au nanoparticles for hGH detection by electrochemical impedance spectroscopy.

Applications

Unspecified application

Species

Unspecified reactive species

Behzad Rezaei,Taghi Khayamian,Najmeh Majidi,Hamidreza Rahmani

Applied microbiology and biotechnology 84:693-9 PubMed19396439

2009

CHO-recombinant human growth hormone as a protease sensitive reporter protein.

Applications

Unspecified application

Species

Unspecified reactive species

Renate Kunert,Willibald Steinfellner,Friedrich Altmann,Jakob Wallner,Hermann Katinger,Karola Vorauer-Uhl

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Growth Hormone 抗体 [GH-1]

Anti-Growth Hormone antibody [GH-1]

Western blot - Anti-Growth Hormone antibody [GH-1] (AB9821)

Western blot - Anti-Growth Hormone antibody [GH-1] (AB9821)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

キャリアフリー

交差種

アプリケーション

免疫原

エピトープ

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (6)

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Abcam product promise