AB22138

Anti-Gremlin 1 抗体

Anti-Gremlin 1 antibody

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(9 Publications)

Rabbit Polyclonal Gremlin 1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Synthetic Peptide within Human GREM1 aa 50-100.

別名を表示する

CKTSF1B1, DAND2, DRM, PIG2, GREM1, Gremlin-1, Cell proliferation-inducing gene 2 protein, DAN domain family member 2, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gremlin 1 antibody (AB22138)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gremlin 1 antibody (AB22138)

Detection of Gremlin 1 in human colon cancer tissue using ab22138 at 5 μg/mL.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human GREM1 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

O60565

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

バッファー組成

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Gremlin 1 often referred to as Gremlin or gremlin-1 protein acts as an antagonist to bone morphogenetic proteins (BMPs). Commonly known as Gremlin 1 protein or Gremlin rat in certain studies it exhibits a mass of approximately 28 kDa. Researchers find Gremlin 1 expressed in various tissues including the kidney lung and limb bud highlighting its presence in numerous developmental processes. Its presence in these tissues indicates its importance in organogenesis and tissue differentiation.

Biological function summary

Gremlin 1 inhibits the BMP pathway which plays an important role in cellular growth and differentiation. It does not function alone; instead it becomes part of a complex interaction network that modulates cell proliferation and embryonic organ development. Gremlin 1's binding to BMPs prevents them from interacting with their receptors affecting the signaling cascade necessary for normal bone and cartilage development as well as vascular patterning.

Pathways

The regulatory function of Gremlin 1 is essential in the BMP signaling pathway. The well-known TGF-beta signaling pathway is influenced by Gremlin 1 as it regulates the balance of BMP activity. Gremlin 1's interaction with BMP4 a closely related protein exemplifies its impact on the differentiation and proliferation of mesenchymal cells.

Gremlin 1 expression has links to fibrotic diseases such as pulmonary fibrosis and chronic kidney disease. These conditions often involve excessive tissue scarring and dysfunction where Gremlin 1's modulation of the BMP pathway exacerbates the fibrosis process. Additionally its interaction with proteins such as BMP7 during these disease states highlights the potential for therapeutic targeting to reverse or inhibit fibrotic progression.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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ターゲットの情報

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed : 27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).

See full target information GREM1

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文献 (9)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 13:1249172 PubMed38045001

2023

Combined score of Y chromosome loss and T-cell infiltration improves UICC based stratification of esophageal adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Verena Maria Raters,Florian Gebauer,Heike Löser,Wolfgang Schröder,Hans Anton Schlösser,Hans Fuchs,Christiane Bruns,Alexander Quaas,Thomas Zander

Stem cells international 2021:8833527 PubMed33953754

2021

NAT10 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Mediating N4-Acetylcytidine Modification of Gremlin 1.

Applications

Unspecified application

Species

Unspecified reactive species

Zhenbiao Zhu,Xiaowei Xing,Shisi Huang,Yuanyuan Tu

Journal of cellular and molecular medicine : PubMed33107676

2020

Role of miR-218-GREM1 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma: An in vivo and vitro study based on microarray data.

Applications

Unspecified application

Species

Unspecified reactive species

Yanpeng Wang,Yifeng Jiang,Long Chen

Pathology oncology research : POR 26:2509-2521 PubMed32583331

2020

Expression of the Serrated Markers Annexin A10 or Gremlin1 in Colonic Adenocarcinomas: Morphology and Prognostic Values.

Applications

Unspecified application

Species

Unspecified reactive species

Benjamin Marquet,Aude Marchal Bressenot,Caroline Fichel,Nicole Bouland,Coralie Barbe,Olivier Bouché,Reza Kianmanesh,Marie-Danièle Diebold,Camille Boulagnon-Rombi

Cancer cell international 19:147 PubMed31143092

2019

Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial-mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Miao,Nuan Wang,Lin-Xin Shi,Zheng Wang,Wen-Bo Song

International journal of oncology 53:2445-2457 PubMed30272371

2018

Overexpression of Gremlin 1 by sonic hedgehog signaling promotes pancreatic cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Yongtian Yu,Liang Cheng,Bin Yan,Cancan Zhou,Weikun Qian,Ying Xiao,Tao Qin,Junyu Cao,Liang Han,Qingyong Ma,Jiguang Ma

Cellular physiology and biochemistry : internation 47:1785-1799 PubMed29953975

2018

Gremlin1 Delivered by Mesenchymal Stromal Cells Promoted Epithelial-Mesenchymal Transition in Human Esophageal Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dongxi Hong,Te Liu,Weijun Huang,Yan Liao,Lin Wang,Zhen Zhang,Haixuan Chen,Xinchun Zhang,Qiuling Xiang

Anticancer research 38:1419-1425 PubMed29491067

2018

Clinicopathological and Prognostic Significance of Epithelial Gremlin1 Expression in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ririno Honma,Naoya Sakamoto,Akira Ishikawa,Daiki Taniyama,Kaho Fukada,Takuya Hattori,Kazuhiro Sentani,Naohide Oue,Kazuaki Tanabe,Hideki Ohdan,Wataru Yasui

Histopathology 69:831-838 PubMed27257976

2016

Gremlin1 expression associates with serrated pathway and favourable prognosis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ari Pelli,Juha P Väyrynen,Kai Klintrup,Jyrki Mäkelä,Markus J Mäkinen,Anne Tuomisto,Tuomo J Karttunen

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Gremlin 1 抗体

Anti-Gremlin 1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Gremlin 1 antibody (AB22138)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (9)

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