Anti-Granzyme A 抗体 [GA6] (ab10870)
Key features and details
- Mouse monoclonal [GA6] to Granzyme A
- Suitable for: IHC-P, IHC-FoFr, WB
- Reacts with: Human
- Isotype: IgG1
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Granzyme A antibody [GA6]
Granzyme A 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [GA6] to Granzyme A -
由来種
Mouse -
アプリケーション
適用あり: IHC-P, IHC-FoFr, WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to Human Granzyme A.
Database link: P12544 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
特記事項（精製）
Purified IgG prepared by affinity chromatography from tissue culture supernatant. -
ポリ/モノ
モノクローナル -
クローン名
GA6 -
ミエローマ
Sp2/0 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab10870の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P | (1) |
Use at an assay dependent concentration.
|
| IHC-FoFr |
Use at an assay dependent concentration. PubMed: 19827750
|
|
| WB |
Use at an assay dependent concentration. Predicted molecular weight: 29 kDa.
Recognises a 60kD disulphide-linked homodimeric protein. |
| 特記事項 |
|---|
|
IHC-P
Use at an assay dependent concentration. |
|
IHC-FoFr
Use at an assay dependent concentration. PubMed: 19827750 |
|
WB
Use at an assay dependent concentration. Predicted molecular weight: 29 kDa. Recognises a 60kD disulphide-linked homodimeric protein. |
ターゲット情報
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機能
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis. -
配列類似性
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain. -
細胞内局在
Secreted. Cytoplasmic granule. - Information by UniProt
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参照データベース
- Entrez Gene: 3001 Human
- Omim: 140050 Human
- SwissProt: P12544 Human
- Unigene: 90708 Human
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別名
- CTL tryptase antibody
- CTLA3 antibody
- Cytolytic t cell and natural killer cell specific trypsin like serine protease antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (4)
ab10870 は 4 報の論文で使用されています。
- Papalampros A et al. Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused CD47-SIRPa Expression. Cancers (Basel) 12:N/A (2020). PubMed: 32645996
- Wu F et al. Molecular subtyping reveals immune alterations in IDH wild-type lower-grade diffuse glioma. J Pathol 251:272-283 (2020). PubMed: 32418210
- Li H et al. Glucocorticoid Receptor and Sequential P53 Activation by Dexamethasone Mediates Apoptosis and Cell Cycle Arrest of Osteoblastic MC3T3-E1 Cells. PLoS One 7:e37030 (2012). WB ; Mouse . PubMed: 22719835
- Hirono S et al. Molecular markers associated with lymph node metastasis in pancreatic ductal adenocarcinoma by genome-wide expression profiling. Cancer Sci : (2009). IHC-FoFr ; Human . PubMed: 19817750
