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AB79516

Anti-GPCR GPR32 抗体

Anti-GPCR GPR32 antibody

4

(2 Reviews)

|

(4 Publications)

Rabbit Polyclonal GPCR GPR32 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human GPR32.

別名を表示する

Probable G-protein coupled receptor 32, GPR32

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR32 antibody (AB79516)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR32 antibody (AB79516)

Left panel : immunofluorescence analysis of A549 cells using ab79516 at a 1/500 dilution. Right panel : same, after pre-incubation with the immunizing peptide.

Western blot - Anti-GPCR GPR32 antibody (AB79516)
  • WB

Unknown

Western blot - Anti-GPCR GPR32 antibody (AB79516)

All lanes:

Western blot - Anti-GPCR GPR32 antibody (ab79516) at 1/500 dilution

Lane 1:

Extracts from A549 cells at 15 µg

Lane 2:

Extracts from A549 cells at 15 µg with immunizing peptide

Predicted band size: 40 kDa

Observed band size: 33 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, ICC/IF

applications

免疫原

Synthetic Peptide within Human GPR32. The exact immunogen used to generate this antibody is proprietary information.

O75388

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

G protein-coupled receptor 32 (GPR32) also known as GPR32 is a member of the G protein-coupled receptors (GPCRs) family characterized by its seven-transmembrane domain structure. The molecular mass of GPR32 is approximately 40 kDa. Researchers typically find GPR32 expression in human tissues such as lung and heart. The receptor interacts with specific ligands activating intracellular signaling pathways that lead to various cellular responses.
Biological function summary

GPR32 plays a role in the immune system regulation and inflammation resolution. It partners with ligand molecules like certain specialized pro-resolving mediators (SPMs) to facilitate anti-inflammatory responses. Scientists study GPR32 as part of the broader network of GPCRs known for their involvement in transmitting signals from the extracellular environment into the cell. By influencing resolution pathways GPR32 helps maintain tissue homeostasis.

Pathways

GPR32 significantly influences the resolution phase of inflammation and integrates into the SPM signaling pathway. It interacts with other proteins such as the ALX/FPR2 receptor which is also known to mediate anti-inflammatory actions. Through these interactions GPR32 contributes to orchestrating inflammatory pathway modulation a critical process for balancing immune responses and promoting tissue repair.

GPR32 has a reported relation with inflammatory conditions and cardiovascular diseases. Researchers have studied its role in chronic inflammation where disrupted regulation might contribute to pathological inflammation persistence. GPR32's involvement in cardiovascular diseases links it to the regulation of blood pressure and vascular inflammation with potential interactions seen with proteins such as NADPH oxidase known to affect oxidative stress within these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

G-protein coupled receptor that binds to several ligands including resolvin D1 (RvD1) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. In macrophages, enhances the RvD1-stimulated phagocytic and clearance functions (PubMed : 20080636). Macrophages migrate less toward different chemoattractant stimuli but phagocytose more microbial particles (PubMed : 26969756). Prevents the increase in Ca(2+) and activation of ERK1/2 used by histamine and its H1 receptor subtype to induce goblet cell secretion by activating PKC and GRK2 to counter-regulate the histamine receptor (PubMed : 23462912).
See full target information GPR32
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

In vitro cellular & developmental biology. Animal 61:331-339 PubMed40064746

2025

Resolvin D1 suppresses inflammation in human fibroblast-like synoviocytes via the p-38, NF-κB, and AKT signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Makoto Yanoshita,Naoto Hirose,Sayuri Nishiyama,Eri Tsuboi,Naoki Kubo,Daiki Kita,Kotaro Tanimoto

JCI insight 6: PubMed34166226

2021

Inflammation resolution circuits are uncoupled in acute sepsis and correlate with clinical severity.

Applications

Unspecified application

Species

Unspecified reactive species

Bakr Jundi,Do-Hyun Lee,Hyungkook Jeon,Melody G Duvall,Julie Nijmeh,Raja-Elie E Abdulnour,Mayra Pinilla-Vera,Rebecca M Baron,Jongyoon Han,Joel Voldman,Bruce D Levy

Journal of thrombosis and haemostasis : JTH 15:802-813 PubMed28079976

2017

Maresin 1 induces a novel pro-resolving phenotype in human platelets.

Applications

Unspecified application

Species

Unspecified reactive species

K L Lannan,S L Spinelli,N Blumberg,R P Phipps

Journal of immunology (Baltimore, Md. : 1950) 193:4980-7 PubMed25320283

2014

Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1.

Applications

Unspecified application

Species

Unspecified reactive species

Hsi-Min Hsiao,Thomas H Thatcher,Elizabeth P Levy,Robert A Fulton,Kristina M Owens,Richard P Phipps,Patricia J Sime
View all publications
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Abcam product promise

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