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AB75559

Anti-GPCR GPR20 抗体

Anti-GPCR GPR20 antibody

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(1 Publication)

Rabbit Polyclonal GPCR GPR20 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human G-protein coupled receptor 20.

別名を表示する

G-protein coupled receptor 20, GPR20

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR20 antibody (AB75559)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR20 antibody (AB75559)

Left panel : immunofluorescence analysis of A549 cells, using 1/500 ab75559; Right panel : same, after pre-incubation with the immunizing peptide.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR20 antibody (AB75559)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPR20 antibody (AB75559)

Left panel : immunohistochemistry analysis of paraffin-embedded human brain tissue using 1/50 ab75559; Right panel : same, after pre-incubation with the immunizing peptide.

Western blot - Anti-GPCR GPR20 antibody (AB75559)
  • WB

Unknown

Western blot - Anti-GPCR GPR20 antibody (AB75559)

All lanes:

Western blot - Anti-GPCR GPR20 antibody (ab75559) at 1/500 dilution

Lane 1:

extracts from LOVO cells at 20 µg

Lane 2:

extracts from LOVO cells at 20 µg with immunizing peptide

Predicted band size: 39 kDa

Observed band size: 42 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, ICC/IF, IHC-P

applications

免疫原

Synthetic Peptide within Human G-protein coupled receptor 20. The exact immunogen used to generate this antibody is proprietary information.

Q99678

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
The antibody was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The G protein-coupled receptor GPR20 also known as GPR20 is a member of the GPCR family characterized by its seven-transmembrane domains. This receptor has a mass of approximately 37 kDa. GPR20 is an orphan receptor meaning its endogenous ligand is not well-defined. The receptor expresses most highly in the gastrointestinal tract and central nervous system although expression in other tissues can also occur. As an orphan GPCR GPR20 can influence intracellular signaling pathways through activation of G proteins.
Biological function summary

GPR20 plays a role in intracellular signaling pathways involving cyclic AMP (cAMP) and phosphatidylinositol. Although not part of a complex GPR20 can interact with various G proteins to transmit signals from the outside to the inside of the cell. This influences various cellular responses such as cell proliferation differentiation and survival. The exact biological functions of GPR20 are still under investigation but can influence physiological processes in the tissues where it is expressed.

Pathways

GPR20 integrates into signaling pathways related to cAMP production and phosphatidylinositol metabolism. GPR20 influences the cAMP signaling pathway potentially impacting processes like neurotransmission. Through this pathway GPR20 can interact with other proteins like adenylate cyclases and various G protein subunits sharing pathways with other GPCRs but exhibiting specific roles based on its tissue distribution and receptor specificity.

Research indicates that GPR20 may have a connection to cancer especially gastrointestinal cancer. The high expression of GPR20 in the gastrointestinal tract makes it a potential target for understanding cancer cell proliferation in this region. Additionally GPR20 might relate to neurological disorders because of its presence in the central nervous system. Its signaling pathways intersect with other proteins like beta-arrestins which play roles in regulating receptor desensitization potentially influencing cancer progression or neurological disease pathology.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
See full target information G-protein coupled receptor 20
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Annals of dermatology 31:154-163 PubMed33911564

2019

Neuropeptides Profile and Increased Innervation in Becker's Nevus.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Seok Kim,Myeong Jin Park,Hye Young Kang,Seung Phil Hong,Byung Cheol Park,Myung Hwa Kim
View all publications
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Abcam product promise

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