AB8104

Anti-GPCR GPR15 抗体

Anti-GPCR GPR15 antibody

(1 Review)

(3 Publications)

Rabbit Polyclonal GPCR GPR15 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GPR15 aa 1-50.

別名を表示する

G-protein coupled receptor 15, Brother of Bonzo, BoB, GPR15

2 Images

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Western blot - Anti-GPCR GPR15 antibody (AB8104)

Lane 1:

Western blot - Anti-GPCR GPR15 antibody (ab8104) at 0.5 µg/mL

Lane 2:

Western blot - Anti-GPCR GPR15 antibody (ab8104) at 1 µg/mL

All lanes:

Human spleen lysate

Predicted band size: 41 kDa

Observed band size: 50 kDa

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Western blot - Anti-GPCR GPR15 antibody (AB8104)

Western blot analysis of GPR15 in human heart lysate with anti- GPR15 (NT) in the absence (lane 1) or presence of specific peptide (lane 2) or non related peptide (lane 3).

All lanes:

Western blot - Anti-GPCR GPR15 antibody (ab8104)

Lane 1:

Human heart lysate in absence of specific peptide

Lane 2:

Human heart lysate in presence of specific peptide

Lane 3:

Human heart lysate in presence of unrelated peptide

Predicted band size: 41 kDa

Observed band size: 50 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

Synthetic Peptide within Human GPR15 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P49685

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }

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製品の詳細

Human immunodeficiency virus (HIV) and related viruses require co-receptors to infect target cells. Some G protein coupled receptors including CCR5, CXCR4, CCR3,CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB (for G protein-coupled receptor 15 and brother of Bonzo, respectively) were recently cloned. This novel G protein-coupled receptor serves as coreceptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1. The ligand for GPR15 has not been identified yet.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The G-protein coupled receptor GPR15 also known as BOB is a seven-transmembrane domain receptor belonging to the GPCR superfamily. While its exact molecular mass varies slightly between species it generally hovers around 40–45 kDa. GPR15 is mainly expressed in the gastrointestinal tract particularly the colon as well as in immune cells like T-cells. The receptor is involved in binding and signal transduction which triggers downstream signaling pathways. Researchers often use GPCR antibodies to study interactions involving GPR15 which holds significance in understanding its mechanical functionality.

Biological function summary

GPR15 functions as a mediator for immune and inflammatory responses. It plays a role in T-cell trafficking to mucosal tissues where it helps manage immune surveillance and response. Its biological function does not seem to involve participation in large protein complexes. The receptor interacts with its ligand GPR15L facilitating signaling cascades that impact immune cell behavior. This interaction is essential for processes like maintaining intestinal homeostasis and could have broader implications in immune system regulation.

Pathways

GPR15 is closely associated with the chemokine-mediated signaling pathways. It modulates the migration and adhesion of immune cells which are critical for maintaining mucosal immunity. GPR15L serves as its ligand in these pathways which highlights their regulatory role in immune responses. GPR15 also intersects with inflammatory cytokine signaling highlighting its involvement in pathways that direct inflammatory responses and immune cell homeostasis in the gut environment.

GPR15 has been linked notably to conditions such as inflammatory bowel disease (IBD) and certain types of cancer particularly colorectal cancer. In IBD GPR15-mediated cell migration can exacerbate inflammatory responses in the intestinal lining. The receptor's overexpression has been observed in colorectal cancer potentially contributing to tumor progression through similar immune modulation pathways. By regulating immune cell traffic GPR15 connects with other proteins involved in disease pathways potentially offering targets for therapeutic interventions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection.

See full target information GPR15

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Anticancer research 42:4679-4687 PubMed36191971

2022

Recombinant Thrombomodulin Has Anti-tumor Effects and Enhances the Effects of Gemcitabine for Pancreatic Cancer Through G-protein Coupled Receptor 15.

Applications

Unspecified application

Species

Unspecified reactive species

Kenei Furukawa,Jianhua Ling,Yichen Sun,Y U Lu,Jie Fu,Rui Marukuchi,Paul J Chiao

Scientific reports 7:692 PubMed28386128

2017

G-protein coupled receptor 15 mediates angiogenesis and cytoprotective function of thrombomodulin.

Applications

Species

Unspecified reactive species

Bin Pan,Xiangmin Wang,Chie Nishioka,Goichi Honda,Akihito Yokoyama,Lingyu Zeng,Kailin Xu,Takayuki Ikezoe

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23:746-756 PubMed28167153

2017

The Fifth Epidermal Growth Factor-like Region of Thrombomodulin Alleviates Murine Graft-versus-Host Disease in a G-Protein Coupled Receptor 15 Dependent Manner.

Applications

Unspecified application

Species

Unspecified reactive species

Bin Pan,Xiangmin Wang,Shinsuke Kojima,Chie Nishioka,Akihito Yokoyama,Goichi Honda,Kailin Xu,Takayuki Ikezoe

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GPCR GPR15 抗体

Anti-GPCR GPR15 antibody

Western blot - Anti-GPCR GPR15 antibody (AB8104)

Western blot - Anti-GPCR GPR15 antibody (AB8104)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

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Abcam product promise