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AB75312

Anti-GPCR GPR119 抗体

Anti-GPCR GPR119 antibody

4

(2 Reviews)

|

(3 Publications)

Rabbit Polyclonal GPCR GPR119 antibody. Suitable for ELISA, WB, IHC-P, ICC/IF, IHC-Fr and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human GPR119 aa 200-250.

別名を表示する

Glucose-dependent insulinotropic receptor, G-protein coupled receptor 119, GPR119

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR119 antibody (AB75312)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR119 antibody (AB75312)

Left panel : immunofluorescence analysis of MCF-7 cells, using 1/500 ab75312. Right panel : same, after pre-incubation with the immunizing peptide.

Western blot - Anti-GPCR GPR119 antibody (AB75312)
  • WB

Unknown

Western blot - Anti-GPCR GPR119 antibody (AB75312)

All lanes:

Western blot - Anti-GPCR GPR119 antibody (ab75312) at 1/500 dilution

Lane 1:

extracts from K562 cells at 30 µg

Lane 2:

extracts from K562 cells at 30 µg with immunising peptide

Predicted band size: 36 kDa

Observed band size: 28 kDa,37 kDa,60 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human, Mouse

アプリケーション

IHC-Fr, IHC-P, ICC/IF, ELISA, WB

applications

免疫原

Synthetic Peptide within Human GPR119 aa 200-250. The exact immunogen used to generate this antibody is proprietary information.

Q8TDV5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" }, "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

GPR119 also known as Glucose-dependent insulinotropic receptor is a G protein-coupled receptor (GPCR) that plays an essential role in metabolic regulation. With a mass of approximately 51 kDa it is expressed mainly in pancreatic beta cells and intestinal enteroendocrine cells. This receptor senses dietary lipids and promotes insulin secretion in response to meals. It also couples with G proteins to initiate intracellular signaling cascades important for energy homeostasis.
Biological function summary

GPR119 functions as a sensor of lipid-derived molecules often acting as an aryl agonist receptor. It is not part of a larger complex but can activate a series of downstream pathways upon ligand binding. When activated by endogenous and synthetic agonists GPR119 stimulates the release of incretin hormones such as GLP-1 and GIP. This hormone release enhances insulin response and promotes optimal glycemic control essential in maintaining blood glucose levels.

Pathways

GPR119 signaling pathway is integral in glucose metabolism and energy balance. It links to both the incretin hormone signaling pathway and the insulin signaling pathway. Upon activation it influences the levels of cAMP an important secondary messenger that modulates several downstream effects including the regulation of the insulin receptor. GPR119 interacts with other proteins such as adenylate cyclase affecting insulin secretion and lipid metabolism.

GPR119 has significant relevance to type 2 diabetes and obesity. Its role in glucose homeostasis and energy balance makes it a potential therapeutic target for these conditions. Researchers examine GPR119 agonists as possible treatments for enhancing insulin secretion and controlling body weight. The receptor is linked to related pathways integrating multiple metabolic signals including those mediated by GLP-1 an important hormone involved in energy regulation and glycemic control.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
See full target information GPR119
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Cell proliferation 58:e13764 PubMed39413003

2024

Terazosin, a repurposed GPR119 agonist, ameliorates mitophagy and β-cell function in NAFPD by inhibiting MST1-Foxo3a signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chenglei Zhang,Jiarui Li,Lijuan Wang,Jie Ma,Xin Li,Yuanyuan Wu,Yanru Ren,Yanhui Yang,Hui Song,Jianning Li,Yi Yang

The Journal of investigative dermatology 140:1909-1918.e8 PubMed32142797

2020

GPR119 Is a Potent Regulator of Human Sebocyte Biology.

Applications

Unspecified application

Species

Unspecified reactive species

Arnold Markovics,Ágnes Angyal,Kinga Fanni Tóth,Dorottya Ádám,Zsófia Pénzes,József Magi,Ágnes Pór,Ilona Kovács,Dániel Törőcsik,Christos C Zouboulis,Tamás Bíró,Attila Oláh

American journal of physiology. Gastrointestinal a 307:G958-67 PubMed25258406

2014

Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index.

Applications

Unspecified application

Species

Unspecified reactive species

Tanya J Little,Nicole J Isaacs,Richard L Young,Raffael Ott,Nam Q Nguyen,Christopher K Rayner,Michael Horowitz,Christine Feinle-Bisset
View all publications
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