Anti-gp78 抗体 (ab76841)
Key features and details
- Rabbit polyclonal to gp78
- Suitable for: IHC-Fr, IHC-P, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-gp78 antibody
gp78 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to gp78 -
由来種
Rabbit -
特異性
ab76841 reacts specifically with the 73 kda (isoform 2) protein. -
アプリケーション
適用あり: IHC-Fr, IHC-P, WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse
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免疫原
Synthetic peptide corresponding to Human gp78 (C terminal).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Constituent: Whole serum -
Concentration information loading... -
精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab76841の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
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| IHC-P |
Use at an assay dependent concentration.
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| WB | (1) |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
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IHC-P
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5. -
パスウェイ
Protein modification; protein ubiquitination. -
配列類似性
Contains 1 CUE domain.
Contains 1 RING-type zinc finger. -
細胞内局在
Endoplasmic reticulum membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 267 Human
- Entrez Gene: 23802 Mouse
- Omim: 603243 Human
- SwissProt: Q9UKV5 Human
- SwissProt: Q9R049 Mouse
- Unigene: 295137 Human
- Unigene: 34641 Mouse
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別名
- AMF receptor antibody
- AMF receptor isoform 1 antibody
- AMF receptor isoform 2 antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (4)
ab76841 は 4 報の論文で使用されています。
- Xu J et al. Expression of autocrine motility factor receptor (AMFR) in human breast and lung invasive micropapillary carcinomas. Int J Exp Pathol 104:43-51 (2023). PubMed: 36576071
- Zhang H et al. AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production. J Exp Med 219:N/A (2022). PubMed: 35333296
- Li Y et al. Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1. Cell Commun Signal 17:22 (2019). PubMed: 30836961
- Jung HS et al. Monoclonal antibodies against autocrine motility factor suppress gastric cancer. Oncol Lett 13:4925-4932 (2017). PubMed: 28599497
