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AB97630

Anti-GMDS 抗体

Anti-GMDS antibody

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(2 Publications)

Rabbit Polyclonal GMDS antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GDP-mannose 4,6 dehydratase aa 50-350.

別名を表示する

GDP-D-mannose dehydratase, GMD, GMDS

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Fragment Protein within Human GDP-mannose 4,6 dehydratase aa 50-350. The exact immunogen used to generate this antibody is proprietary information.

O60547

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代替製品

Primary Antibodies

AB238613

Anti-GMDS antibody

Immunocytochemistry/ Immunofluorescence - Anti-GMDS antibody (AB238613)

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組合せ製品

Proteins & Peptides

AB113860

Recombinant Human GMDS protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human GMDS protein (His tag N-Terminus) (AB113860)

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  • 0
Assay Kits

AB107921

Proteasome Activity Assay Kit

Functional Studies - Proteasome Activity Assay Kit (AB107921)

  • 4
  • 2
Assay Kits

AB204718

Succinate Assay Kit (Colorimetric)

Functional Studies - Succinate Assay Kit (Colorimetric) (AB204718)

  • 5
  • 1
Assay Kits

AB204726

Angiogenesis Assay Kit (In Vitro)

Functional Studies - Angiogenesis Assay Kit (In Vitro) (AB204726)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The GMDS protein also known as GDP-mannose 46-dehydratase plays an important role in catalyzing the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose one step in the biosynthesis of GDP-fucose. It has an approximate mass of 39 kDa and predominantly expresses in the liver kidneys and certain immune cells. The GMDS enzyme operates in the cytosol contributing to cellular metabolism and energy balance providing substrates necessary for further enzymatic conversions.
Biological function summary

GMDS contributes significantly to the fucosylation process a modification critical for the functioning of various glycoproteins and glycolipids. It participates in the synthesis of fucose which serves as a substrate for fucosyltransferases in glycan decorations. The enzymatic activity of GMDS occurs as part of a greater network within the cytosol although it does not directly involve multi-protein complexes. Its product GDP-fucose plays a role in cell-cell interaction and communication emphasizing GMDS’s importance in cell biology and molecular signaling.

Pathways

GMDS contributes to the fucose biosynthesis pathway and indirectly affects the Leloir pathway of galactose metabolism due to interconnected metabolic pools. Through its product GDP-fucose GMDS links to proteins such as fucosyltransferases which incorporate fucose into glycan structures. The availability of fucose also affects signaling pathways involving Notch receptor activation influencing cellular differentiation and growth making GMDS an essential player in glycan-related signal transduction.

GMDS alterations have connections with immunodeficiencies and various cancer types. Deficiencies in GMDS can lead to Congenital Disorder of Glycosylation Type Iic where improper glycosylation affects immune cell functions and fucosylation imbalance links to increased tumor progression and metastasis through altered cell surface glycan structures. In the context of these disorders GMDS influences proteins such as alpha-13-fucosyltransferases with fucose content affecting functional glycan patterns on cells demonstrating its importance in pathophysiology related to glycosylation disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
See full target information GDP-mannose 4,6 dehydratase
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39684386

2024

Knockdown Induces Obesity and AHO Features in Early Zebrafish Larvae.

Applications

Unspecified application

Species

Unspecified reactive species

Alaa Abbas,Ayat S Hammad,Zain Z Zakaria,Maha Al-Asmakh,Khalid Hussain,Mashael Al-Shafai

Biotechnology progress 37:e3061 PubMed32748555

2020

Generation of FX and Gmds CHOZN host cell lines for the production of afucosylated therapeutic antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Weiyi Liu,Roshan Padmashali,Omar Quintero Monzon,Dianna Lundberg,Shan Jin,Brian Dwyer,Yun-Jung Lee,Anisha Korde,Sophia Park,Clark Pan,Bohong Zhang
View all publications
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Abcam product promise

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