Anti-Glypican 3 抗体 (ab186872)
Key features and details
- Rabbit polyclonal to Glypican 3
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-Glypican 3 antibody
Glypican 3 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Glypican 3 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant full length protein corresponding to Human Glypican 3 aa 1-580.
Database link: P51654 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab186872の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/2000. Predicted molecular weight: 66 kDa.
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| 特記事項 |
|---|
|
WB
1/500 - 1/2000. Predicted molecular weight: 66 kDa. |
ターゲット情報
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機能
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. -
組織特異性
Highly expressed in lung, liver and kidney. -
関連疾患
Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. -
配列類似性
Belongs to the glypican family. -
細胞内局在
Cell membrane and Secreted > extracellular space. - Information by UniProt
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参照データベース
- Entrez Gene: 2719 Human
- Entrez Gene: 14734 Mouse
- Omim: 300037 Human
- SwissProt: P51654 Human
- SwissProt: Q8CFZ4 Mouse
- Unigene: 644108 Human
- Unigene: 22515 Mouse
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別名
- DGSX antibody
- Glypican proteoglycan 3 antibody
- Glypican-3 [Precursor] antibody
see all
画像
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Western blot - Anti-Glypican 3 antibody (ab186872)All lanes : Anti-Glypican 3 antibody (ab186872) at 1/500 dilution
Lane 1 : BT474 cell lysate
Lane 2 : MCF7 cell lysate
Lane 3 : HepG2 cell lysate
Lane 4 : 22RV-1 cell lysate
Lane 5 : Mouse kidney lysate
Lane 6 : Mouse testis cell lysate
Predicted band size: 66 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab186872 は 3 報の論文で使用されています。
- Kopasz AG et al. A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver. BMC Biol 20:74 (2022). PubMed: 35361222
- Kerdput V et al. Therapeutic efficacy of a Dioscorea membranacea extract in a rat model of hepatocellular carcinoma: Histopathological aspects. J Tradit Complement Med 11:400-408 (2021). PubMed: 34522634
- Ni Q et al. Deletion of HNF1a in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice. FEBS Lett 591:1947-1957 (2017). PubMed: 28547778